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HSP90抑制剂17-DMAG在调节纤维化治疗中METTL3的治疗潜力

Soo Min Lee1, Myoung Seok Lee2, Hae Rim Jung3

  • 1College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea.

Journal of the American Society of Nephrology : JASN
|January 26, 2026
PubMed
概括

17-Dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) 通过降低METTL3的调节,有效地减少纤维化,这是纤维化的关键驱动因素. 这种药物重用策略为慢性脏病 (CKD) 提供了一个有前途的新治疗途径.

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