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在膀癌的器官节约三模式治疗后,ctDNA动态和复发模式.
Ilana B Epstein1, Adetolani Odogiyon2, Stephanie Berg3
1Dana-Farber Cancer Institute Boston United States.
概括
血循环瘤DNA (ctDNA) 可以预测肌肉侵入性膀癌 (MIBC) 患者的转移性复发,这些患者接受了三模式治疗 (TMT). 然而,ctDNA与MIBC的TMT后的局部疾病复发无关.
科学领域:
- 在瘤学瘤学.
- 分子诊断学 分子诊断学
背景情况:
- 肌肉侵入性膀癌 (MIBC) 是一个重大的健康问题.
- 三种疗法 (TMT) 为MIBC提供了囊切除术的膀节省替代方案.
- 血循环瘤DNA (ctDNA) 在监测治疗反应方面表现有前途,但其在MIBCTMT中的作用尚不清楚.
研究的目的:
- 调查血ctDNA与接受TMT的MIBC患者的临床结果之间的关联.
- 为了确定ctDNA是否可以预测MIBCTM后的转移性与局部复发.
主要方法:
- 在两个主要的癌症中心对84名MIBC患者进行TMT治疗的前性研究.
- 在基线和治疗后使用SignateraTM试验进行ctDNA分析.
- ctDNA状态与临床疾病状态的相关性,包括转移性和局部复发.
主要成果:
- 19%的患者在化疗放射治疗 (CRT) 之前在基线检测到ctDNA.
- 在CRT后检测到的ctDNA与转移性复发有很强的相关性 (p<0.0001).
- 在TMT后的ctDNA和局部膀复发之间没有发现任何关联.
结论:
- 血ctDNA是一种有价值的生物标志物,用于预测接受TMT治疗的MIBC患者转移性复发.
- 在TMT后ctDNA可检测性并不表明本地疾病复发.
- 进一步的研究可以探索将ctDNA监测集成到MIBC的TMT监测协议中.
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