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韩国患者中度至重度补充性水腺炎对secukinumab的临床和转录组反应

Sujin Moon, Young In Lee, Hyun Ah Kwon

Dermatology (Basel, Switzerland)

|January 26, 2026

概括

在韩国患者中,secokinumab有效治疗中度至重度的上腺炎 (HS),显示出显著的临床反应并影响疾病途径. 这支持其在亚洲人群中的使用.

科学领域:

皮肤病学皮肤病学
免疫学免疫学免疫学
基因组学就是基因组学.

背景情况:

补腺炎 (HS) 是一种慢性炎症性皮肤疾病,在亚洲人群中治疗数据有限.
像secokinumab这样的IN-17 (IL-17) 抑制剂对中度至重度的HS表现有前途.

研究的目的:

评估secukinumab在韩国中度至重度HS患者的临床有效性.
探索secukinumab治疗如何改变HS病变中的基因表达.

主要方法:

25名韩国患者中度至重度的HS接受了secukinumab (300mg) 治疗16周.
定期评估临床结果,包括腺炎辅助性临床反应 (HiSCR) 和国际腺炎辅助性严重性评分系统 (IHS4).
从3名患者的皮肤活检的RNA测序分析了基因表达在基线和第12周的变化.

主要成果:

86.96%的患者在第16周实现了HiSCR.
78.26%的人在IHS4得分中出现了≥55%的降低.
转录组分析显示,与皮肤发育和细胞增殖有关的途径发生了变化.

结论:

塞库金纽马布在韩国患者中度至重度HS中表现出显著的临床疗效.
治疗调节了参与HS病变发生的关键分子通路.
这些发现支持sequukinumab在亚洲人群中的治疗潜力,并提供了对IL-17阻断机制的见解.

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