阿科鲁斯 L. 提取物在老鼠模型中对辐射诱导的皮肤损伤的治疗作用
Xiaodan Wu1, Yanan Tong1, Wenxuan Luo2
1Department of Nuclear Medicine, General Hospital of Northern Theater Command.
Journal of visualized experiments : JoVE
|January 26, 2026
概括
在老鼠中,Acorus calamus L. 提取物显著改善了辐射诱导的皮肤损伤愈合. 它减少了炎症和亡,同时促进了新的血管生长,为辐射损伤提供了潜在的治疗方法.
科学领域:
- 皮肤病学 皮肤病学
- 药理学 药理学是指药理学的学科.
- 在瘤学瘤学.
背景情况:
- 辐射诱导的皮肤损伤是癌症治疗的常见,痛苦的副作用.
- 放射性皮肤炎的有效治疗方法有限.
- 阿科鲁斯·卡拉马斯L. (AC) 对皮肤疾病有希望,但需要对辐射损伤进行调查.
研究的目的:
- 评估Acorus calamus L. 提取物在治疗辐射引起的皮肤损伤中的疗效.
- 评估AC对伤口愈合,炎症,亡和血管生成的影响.
主要方法:
- 使用了一种斯普拉格-道利老鼠模型,通过45 Gy辐射诱导皮肤损伤.
- 鼠类接受了10%,20%或40%的AC提取物,持续45天.
- 评估包括伤口愈合率,组织病理学,细胞因子分析,TUNEL和VEGF和bFGF的免疫组织化学.
主要成果:
- AC治疗加速了伤口愈合,20%的组在45天内显示了88.97%的愈合.
- 组织学显示,炎症减少,原蛋白结构更好,血管化增加.
- 在AC下降了炎症性细胞因子 (IL-1β,IL-6,TNF-α),减少了亡 (调节P53,Bax,Bcl-2),以及增加了亲血管性因子 (VEGF,bFGF).
结论:
- 阿科鲁斯·卡拉马斯L.提取物有效地促进辐射诱导的皮肤损伤的愈合.
- 通过减少炎症,抑制细胞亡和增强血管生成,AC减轻了辐射损伤.
- AC提出了一个潜在的治疗策略,用于管理癌症患者的放射性皮肤炎.
更多相关视频
06:21Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model
Published on: May 27, 2016
8.6K
06:53A Rat Carotid Artery Pressure-Controlled Segmental Balloon Injury with Periadventitial Therapeutic Application
Published on: July 9, 2020
5.6K
相关概念视频
Biological Effects of Radiation
17.8K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
17.8K
Extraction: Effects of pH
1.4K
Consider a neutral form of an amine, B, with a partition coefficient, K, in a liquid mixture containing organic and aqueous phases. The pH of the aqueous phase affects the charge on acidic and basic solutes, and the charged form is usually more soluble in the aqueous phase. Suppose the conjugate acid form of the amine is soluble only in the aqueous phase while the base form is soluble in both phases. Then the distribution coefficient, D, can be given as the ratio of amine concentration in the...
1.4K
Antipsychotic Drugs: Therapeutic Uses and Side Effects
815
Antipsychotic drugs primarily block dopamine and serotonin receptors and cholinergic, adrenergic, and histaminergic receptors, thereby reducing hallucinations and delusions in conditions like schizophrenia. However, they can trigger unwanted extrapyramidal effects such as dystonias, Parkinson-like symptoms, and tardive dyskinesia.
Despite these side effects, antipsychotics are used therapeutically for various purposes, including managing schizophrenia, preventing nausea and vomiting, curbing...
Despite these side effects, antipsychotics are used therapeutically for various purposes, including managing schizophrenia, preventing nausea and vomiting, curbing...
815
Induced-fit Model
89.1K
Most chemical reactions in cells require enzymes—biological catalysts that speed up the reaction without being consumed or permanently changed. They reduce the activation energy needed to convert the reactants into products. Enzymes are proteins, that usually work by binding to a substrate—a reactant molecule that they act upon.
Enzymes exhibit substrate specificity, meaning that they can only bind to certain substrates. This is mainly determined by the shape and chemical...
Enzymes exhibit substrate specificity, meaning that they can only bind to certain substrates. This is mainly determined by the shape and chemical...
89.1K
Radiation: Applications
1.8K
The average temperature of Earth is the subject of much current discussion. Earth is in radiative contact with both the Sun and dark space; it receives almost all its energy from the radiation of the Sun and reflects some of it into outer space. Dark space is very cold, about 3 K, so Earth radiates energy into it. For instance, heat transfer occurs from soil and grasses, the rate of which can be so rapid that frost can occur on clear summer evenings, even in warm latitudes.
The average...
The average...
1.8K
Absorption of Radiation
1.3K
The rate of heat transfer by emitted radiation is described by the Stefan-Boltzmann law of radiation:
1.3K
