顺序双目标TMS对大脑网络动态特征的影响,由fNIRS揭示
概括
顺序双目标跨磁刺激 (TMS) 优化了中风患者的大脑网络动态,通过维持低能量的状态和减少低效的过渡,优于单个目标方法. 动态功能连接模式可以预测运动功能的恢复.
科学领域:
- 神经科学是一个神经科学.
- 康复医学 康复医学 康复医学
- 生物医学工程 生物医学工程
背景情况:
- 跨磁性刺激 (TMS) 调节皮层刺激性以促进神经可塑性.
- 单个目标的TMS在增强多区域大脑网络协同作用方面存在局限性.
- 序列双目标TMS用于大脑网络重组的机制需要进一步研究.
研究的目的:
- 调查单个和连续的双目标TMS对中风患者大脑功能网络的直接影响.
- 用功能近红外光谱学 (fNIRS) 分析动态功能连接 (dFNC) 状态和过渡.
- 探索dFNC模式与中风幸存者的运动功能之间的关系.
主要方法:
- 使用fNIRS记录15名亚急性中风患者和15名健康对照者的大脑活动.
- 使用单向的SMA-rTMS,单向的LDLPFC-rTMS和连续的双向的rTMS (双rTMS).
- 使用dFNC分析了fNIRS数据,以评估连接状态,时间分数,状态转换,全球效率和总信号功率.
主要成果:
- 确定了三个dFNC状态:连接性弱 (状态1),中等 (状态2) 和强 (状态3).
- 与单个目标的TMS相比,双rTMS延长了状态1 (低连接),并减少了低效的状态过渡.
- 脑卒中患者表现出状态2→3过渡的损伤;状态3时间分数与运动功能 (FMA-LE,BBS) 呈正相关,而状态1与运动功能呈负相关.
结论:
- 连续的双目标TMS通过促进低能量的状态和抑制不适应性过渡来增强大脑网络动态,比单个目标方法提供优势.
- dFNC 时间模式显示出作为中风后运动功能的生物标志物的潜力.
- 顺序双目标TMS代表了中风康复的有前途的治疗策略.
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