结构和语义意识到多视图对比学习,用于预测lncRNA,miRNA和疾病之间的关联
IEEE journal of biomedical and health informatics
|January 26, 2026
概括
我们开发了SSMVCL,这是一个新的计算框架,用于预测长非编码RNA (lncRNA) -疾病关联 (LDA),miRNA-疾病关联 (MDA) 和lncRNA-miRNA相互作用 (LMI). 这种方法改善了精准医学中的生物标志物发现.
科学领域:
- 生物信息学是一种生物信息学.
- 计算生物学 计算生物学
- 基因组学就是基因组学.
背景情况:
- 识别长非编码RNAs (lncRNAs),microRNAs (miRNAs) 和疾病之间的关联对于生物标志物发现和精准医学至关重要.
- 目前的计算方法由于已知的关联稀疏和复杂的生物网络而面临限制.
研究的目的:
- 提出SSMVCL (结构和语义意识的多视图对比学习),一个统一的框架来预测lncRNA-疾病关联 (LDA),miRNA-疾病关联 (MDA) 和lncRNA-miRNA相互作用 (LMI).
主要方法:
- 使用多源生物数据构建了一个异构的生物信息网络.
- 采用了局部拓学的结构意识视图和含义意识视图,用于高阶关系的元路径.
- 使用交叉视图对比对齐模块与自适应负采样来增强一致性和辨别力.
主要成果:
- 在两个基准数据集上,SSMVCL实现了最先进的性能.
- 在数据集2.2.上,为LDA (0.9736/0.9716),MDA (0.9364/0.9309) 和LMI (0.9297/0.9234) 实现了高AUC/AUPR值.
- 关于胃癌和前列腺癌的案例研究表明了强度,并确定了支持的关联.
结论:
- SSMVCL提供了一种强大且统一的方法来预测lncRNA与疾病的关联,miRNA与疾病的关联以及lncRNA与miRNA的相互作用.
- 该框架显示了通过精确预测分子相互作用和疾病关联来推进生物标志物发现和精准医学的巨大潜力.
相关概念视频
Associative Learning
1.3K
Associative learning is a fundamental concept in behavioral psychology, wherein a connection is established between two stimuli or events, leading to a learned response. This process is critical in understanding how behaviors are acquired and modified. Conditioning, the mechanism through which associations are formed, can be divided into two main types: classical conditioning and operant conditioning, each elucidating different aspects of associative learning.
Classical conditioning, also known...
Classical conditioning, also known...
1.3K
Self-Awareness and Its Effects
308
Self-awareness is a psychological state in which the individual becomes the focal point of their attention. This inward focus transforms the self into an object of contemplation and assessment, influencing how individuals perceive their actions and their alignment with personal and societal standards.Triggers and Contexts for Self-AwarenessSelf-awareness can be activated by external stimuli that make individuals visually or audibly aware of themselves, such as mirrors, cameras, or recordings.
308
Altered States of Awareness
1.1K
Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
1.1K
Subconsciousness and No Awareness
701
The concept of subconscious awareness refers to the processing of information below the level of conscious thought, which significantly influences both behaviors and decisions. It is also known as waking subconscious awareness. This complex level of cognition operates without the direct awareness of the individual, facilitating rapid and simultaneous handling of multiple information streams.
An illustrative example of subconscious processing is its role in problem-solving. Often, individuals...
An illustrative example of subconscious processing is its role in problem-solving. Often, individuals...
701
High-Level and Low-Level Awareness
680
Controlled processes in human consciousness represent high-alert mental states where individuals deliberately focus their attention on achieving specific goals. Controlled processes can be seen in situations like mastering new technology, where a person might become so absorbed that they ignore surrounding distractions. Such processes involve selective attention, requiring one to concentrate on particular elements of experience while disregarding others. These are governed by executive...
680
Predicting Molecular Geometry
45.7K
VSEPR Theory for Determination of Electron Pair Geometries
45.7K


