Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Histone Modification02:32

Histone Modification

16.1K
The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
16.1K
Histone Modification02:32

Histone Modification

4.5K
4.5K
Spreading of Chromatin Modifications02:25

Spreading of Chromatin Modifications

9.4K
The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer...
9.4K
Overview of the Cardiovascular System01:14

Overview of the Cardiovascular System

11.7K
The cardiovascular system is a vital transportation system in the body. It comprises the heart and blood vessels and facilitates the exchange of gases, nutrients, and waste products.
Heart
The heart is the central pump of the cardiovascular system that circulates blood throughout the body. It comprises two atria receiving the blood and two ventricles pumping blood out of the heart. Their rhythmic contractions, called heartbeats, ensure that blood flow remains continuous.
Blood Vessels
Blood...
11.7K
Relative Risk01:12

Relative Risk

2.1K
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
2.1K
Regulation of the Cardiovascular System01:27

Regulation of the Cardiovascular System

3.9K
The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
3.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Challenges and Future Trends in Large Vessel Vasculitis.

Circulation·2026
Same author

Utility and cost of umbilical cord methicillin-resistant Staphylococcus aureus surveillance testing in neonates.

American journal of infection control·2026
Same author

Chasing the target: reports from the Advances in Targeted Therapies meeting, 2025.

Annals of the rheumatic diseases·2026
Same author

Post-operative tracheitis in the NICU: incidence and risk factors.

Journal of perinatology : official journal of the California Perinatal Association·2026
Same author

Pressure in Practice: A New Clinical Case Series in <i>Hypertension</i>.

Hypertension (Dallas, Tex. : 1979)·2026
Same author

IDEA-FAST clinical study protocol: Identifying digital end-points of fatigue, sleep quality and daytime sleepiness in N = 2000.

Digital health·2026
Same journal

A Bundle to Frame Guidelines and American Heart Association Statements.

Circulation·2026
Same journal

<i>Circulation</i> Editors and Editorial Board.

Circulation·2026
Same journal

A New <i>Circulation</i>, For You.

Circulation·2026
Same journal

Cardiovascular Risk Reduction With GLP-1 RA Drugs.

Circulation·2026
Same journal

Obesity, Severe Obesity, and Abdominal Obesity in US Youth and Adults From 1999 to 2023.

Circulation·2026
Same journal

Lipid Profile Testing and Interpretation.

Circulation·2026
查看所有相关文章

相关实验视频

Updated: Jan 28, 2026

Fundus Photography as a Convenient Tool to Study Microvascular Responses to Cardiovascular Disease Risk Factors in Epidemiological Studies
10:11

Fundus Photography as a Convenient Tool to Study Microvascular Responses to Cardiovascular Disease Risk Factors in Epidemiological Studies

Published on: October 22, 2014

19.6K

目前和未来的塔卡亚苏动脉炎治疗方法:对心血管风险进行修改

Alexandra Armstrong1, Dan Pugh1, Neil Basu2

  • 1Edinburgh Kidney, BHF/The Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, UK (A.A., D.P., N.D.).

Circulation
|January 26, 2026
PubMed
概括
此摘要是机器生成的。

塔卡亚苏动脉炎 (TAK) 管理需要改变模式. 目前的治疗方法有很高的复发率,无法降低心血管风险,因此需要综合方法来实现长期缓解和降低死亡率.

关键词:
塔卡亚苏动脉炎心脏病的危险因素血管炎

更多相关视频

Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis
07:51

Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis

Published on: September 26, 2018

8.0K
Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
06:04

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

1.4K

相关实验视频

Last Updated: Jan 28, 2026

Fundus Photography as a Convenient Tool to Study Microvascular Responses to Cardiovascular Disease Risk Factors in Epidemiological Studies
10:11

Fundus Photography as a Convenient Tool to Study Microvascular Responses to Cardiovascular Disease Risk Factors in Epidemiological Studies

Published on: October 22, 2014

19.6K
Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis
07:51

Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis

Published on: September 26, 2018

8.0K
Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
06:04

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

1.4K

科学领域:

  • 风湿病学和免疫学
  • 心血管医学
  • 血管生物学

背景情况:

  • 塔卡亚苏动脉炎 (TAK) 是一种罕见的,免疫媒介的大血管炎,主要影响年轻女性.
  • 它带有血管并发症和长期心血管疾病的重大风险.
  • 目前的治疗方法,包括葡萄皮质类药物和免疫抑制剂,复发率很高,并不足以应对未来的心血管风险.

研究的目的:

  • 综合目前高山动脉炎治疗策略和未满足需求的证据.
  • 探索新的免疫和血管向疗法.
  • 倡导管理模式转向综合降低心血管风险.

主要方法:

  • 关于高山动脉炎发病,诊断和治疗的当前文献的审查.
  • 对现有疗法 (皮质糖类药物,DMARD,生物药物) 的批判性评估.
  • 探索针对新的炎症和信号通路的新兴疗法.

主要成果:

  • 了解TAK病变的进展凸显了先天性和适应性免疫的作用.
  • 新兴疗法针对IL-17,IL-12/23,JAK/STAT和Notch-1/mTOR等途径.
  • 心血管疾病是TAK死亡的主要原因,需要综合风险因素修改.

结论:

  • 目前的塔卡亚苏动脉炎治疗受到诊断不确定性,异质方法和缺乏高质量的试验的限制.
  • 未来的干预措施必须针对免疫介导的血管损伤和心血管疾病的进展.
  • 实现长期的疾病缓解和降低心血管死亡率应该是治疗的主要目标.