相关实验视频

Updated: Jan 28, 2026

The NeuroStar TMS Device: Conducting the FDA Approved Protocol for Treatment of Depression
10:29

The NeuroStar TMS Device: Conducting the FDA Approved Protocol for Treatment of Depression

Published on: November 12, 2010

40.5K

经FDA批准的小分子蛋白激酶抑制剂的特性:2026年更新

Robert Roskoski1

  • 1Blue Ridge Institute for Medical Research, 221 Haywood Knolls Drive, Hendersonville, North Carolina 28791, United States.

Pharmacological research
|January 26, 2026
PubMed
概括

蛋白激酶是主要的药物标,有94种FDA批准的抑制剂,包括2025年10种新的抑制剂. 本综述详细介绍了它们的物理化学特性和在癌症和炎症性疾病中的治疗应用.

关键词:
亚美丁尼布 (PubChem CID: 16719221) 是一种药物.慢性免疫性血小板减少症.慢性自发性 ?? 疹.德法提尼布 (PubChem CID: 25117126) 的使用情况德尔戈提尼布 (PubChem CID: 50914062) 是一种药物,它可以手上的湿疹手湿疹.米达美提尼布 (PubChem CID: 9826528) 是一种药物.突变EGFR,HER2和ROS1非小细胞肺癌卵巢癌是发生在卵巢中的癌症.雷米布鲁丁尼布 (PubChem CID: 118107483) 是一种药物.里尔扎布鲁丁尼布 (PubChem CID: 73388818) 的使用情况孙沃泽提尼布 (PubChem CID: 139377809) 是一种药物.塔莱特雷克提尼布 (PubChem CID: 72202474) 的使用情况紧缩性巨细胞瘤维姆塞尔提尼布 (PubChem CID: 86267612) 是一种药物.格尔提尼布 (PubChem CID: 160283094) 是一种可以使用的药物.

更多相关视频

Generation of Recombinant Arenavirus for Vaccine Development in FDA-Approved Vero Cells10:03

Generation of Recombinant Arenavirus for Vaccine Development in FDA-Approved Vero Cells

Published on: August 1, 2013

17.6K
Kinase Inhibitor Screening In Self-assembled Human Protein Microarrays13:22

Kinase Inhibitor Screening In Self-assembled Human Protein Microarrays

Published on: October 23, 2019

8.3K

相关概念视频

FDA Approved Drugs: Changes to Approved Drugs01:26

FDA Approved Drugs: Changes to Approved Drugs

Post-approval, manufacturers may modify an approved new or generic drug product. Such modifications can encompass alterations in the Active Pharmaceutical Ingredient (API), manufacturing process, formulation, batch size, manufacturing site, and container closure system (FDA Guidance for Industry, April 2004). Often, a drug product may undergo multiple changes.These modifications require careful evaluation to determine their potential impact on the drug product's identity, strength, quality,...
256
Protein Kinases and Phosphatases02:54

Protein Kinases and Phosphatases

Proteins undergo chemical modifications that trigger changes in the charge, structure, and conformation of the proteins. Phosphorylation, acetylation, glycosylation, nitrosylation, ubiquitination, lipidation, methylation, and proteolysis are various protein modifications that regulate protein activity. Such modifications are usually enzyme-driven.
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
15.1K
Protein Kinases and Phosphatases02:54

Protein Kinases and Phosphatases

4.5K
Kinetic Molecular Theory and Gas Laws Explain Properties of Gas Molecules02:34

Kinetic Molecular Theory and Gas Laws Explain Properties of Gas Molecules

The test of the kinetic molecular theory (KMT) and its postulates is its ability to explain and describe the behavior of a gas. The various gas laws (Boyle’s, Charles’s, Gay-Lussac’s, Avogadro’s, and Dalton’s laws) can be derived from the assumptions of the KMT, which have led chemists to believe that the assumptions of the theory accurately represent the properties of gas molecules.
37.4K
cAMP-dependent Protein Kinase Pathways01:25

cAMP-dependent Protein Kinase Pathways

Cyclic Adenosine Monophosphate (cAMP) is an essential second messenger that activates protein kinase A (PKA) and regulates various biological processes. A single epinephrine molecule binds to GPCR and activates several heterotrimeric G proteins, each stimulating multiple adenylyl cyclase, amplifying the signal, and synthesizing large numbers of cAMP molecules. Small changes in cAMP concentration affect PKA activity. The binding of four cAMP molecules induces a conformational change in PKA,...
8.4K
Eukaryotic Transcription Inhibitors01:52

Eukaryotic Transcription Inhibitors

Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding proteins known as eukaryotic transcription inhibitors regulate the repression of gene expression in eukaryotes. The presence of these inhibitors at the required location and time in the cell is triggered by the presence of hormones and additional signals from other cells.
Eukaryotic transcription inhibitors usually contain two distinct domains, a...
11.0K