视觉皮层功能连接性改变及其与早期出现双相情感障碍精神病症状的关联
Zheng Bi1, Meng Li2, Mengqian Li3
1Department of Radiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China; Department of Psychiatry, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330004, China.
Journal of affective disorders
|January 26, 2026
概括
早期出现的双相情感障碍 (EOBD) 显示视觉系统连接的改变,额头连接增加和感觉运动联系的减少. 这些与视觉相关的功能连接性变化可能表明EOBD的早期精神病脆弱性.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 神经成像是一种神经成像.
背景情况:
- 视觉皮层功能障碍与精神病和症状有关.
- 早期出现的双相情感障碍 (EOBD) 的视觉区域的功能连接 (FC) 尚不清楚.
- 这项研究调查了EOBD中与视觉相关的FC变化.
研究的目的:
- 检查EOBD中与视觉相关的FC变化.
- 在EOBD中探索改变FC和精神症状之间的关联.
- 识别潜在的精神病脆弱性的早期标志物.
主要方法:
- 在88名EOBD个体和56名健康对照 (HCs) 中使用了休息状态功能性MRI.
- 对25个视觉皮质区域进行了基于种子的功能连接 (FC) 分析.
- 部分相关性检查了FC和精神症状之间的关联.
主要成果:
- EOBD显示视觉种子和额头/部区域 (14种子) 之间的FC较高.
- 电气车辆驾驶仪表显示视觉种子和时间/感觉运动区域 (5种种子) 之间的FC较低.
- 精神病症状与视觉和额头区域的较高FC相关,包括LO1,LO2,hMT/V5,IPS5,前中心和上额头回转.
结论:
- EOBD显示了视觉系统连接的改变,前部连接增加,感觉运动/情绪调节连接减少.
- 与视觉相关的FC异常可能在双相情感障碍 (BD) 的早期出现.
- 这些异常与精神病症状有关,并可能作为早期脆弱性标志物.
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