基于挤出的骨架的增材制造
Keyu Chen1, Jiahui Dong1, Niko Eka Putra1
1Department of Biomechanical Engineering, Faculty of Mechanical Engineering, Delft University of Technology, Mekelweg 2, 2628 CD, Delft, The Netherlands.
Acta biomaterialia
|January 26, 2026
概括
基于挤出的增材制造成功地为骨组织工程创造了多孔的支架,克服了蒸发的挑战. 这些支架表现出类似骨的机械特性和受控的生物降解,显示出牙科和骨科植入物的前景.
科学领域:
- 生物材料工程 生物材料工程
- 增材制造 增材制造 增材制造
- 材料科学 材料科学 材料科学
背景情况:
- (Zn) 是一个有前途的可生物降解金属,用于骨组织工程.
- 基于激光的增材制造 (AM) 面临着蒸发和池不稳定的挑战.
- 开发Zn支架的替代AM策略至关重要.
研究的目的:
- 使用基于挤出的AM制造多孔支架.
- 为了优化油墨配方和高保真支架的烧结参数.
- 为了描述制造的支架的多孔性,机械性质,生物降解性和细胞相容性.
主要方法:
- 系统的油墨配方,50-56体积%的 Zn 负载.
- 用于优化印刷能力的风湿学分析.
- 基于挤出的AM用于脚手架制造.
- 在特定温度窗口内的烧结优化.
- 用于结构性特征的SEM和微CT.
- 在模拟体液 (r-SBF) 中进行体外生物降解试验.
- 电化学试验用于腐蚀分析.
- 间接和直接的细胞兼容性测定与MC3T3-E1细胞.
主要成果:
- 用53%体积墨水打印并在415°C5小时内烧结的优化脚手架实现了40 ± 3%的多孔度,最小的Zn蒸发.
- 脚手架表现出模仿骨的机械性能 (压力强度为16.1 ± 1.3 MPa,弹性模块为1.4 ± 0.1 GPa).
- 试验室生物降解显示了低腐蚀率 (0.03±0.01毫米/年),形成了ZnO和酸.
- 电化学测试表明了被动化行为和增加极化阻力.
- 细胞相容性测定证实了>90%的细胞代谢活性和良好的细胞粘附.
结论:
- 基于挤出的AM是一种可行的方法,用于制造多孔Zn支架.
- 开发的工艺允许量身定制的多孔性,受控的生物降解和类似骨的机械性能.
- 这些Zn支架表现出可接受的细胞兼容性,提高了它们对可生物降解的骨植入物的潜力.
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