更年期和激素替代疗法的情绪和认知影响
Katharina Zuhlsdorff1, Christelle Langley2, Richard Bethlehem1
1University of Cambridge Department of Psychology, UK.
Psychological medicine
|January 26, 2026
概括
更年期会对心理健康和大脑结构产生负面影响,减少灰质体积. 激素替代疗法 (HRT) 没有改善这些结果,可能与增加的心理健康问题相关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 内分泌学 在内分泌学.
背景情况:
- 更年期是一个自然的过渡期,对大脑的影响尚不清楚.
- 荷尔蒙替代疗法 (HRT) 被英国15%的女性用于治疗更年期症状.
- 对于HRT的心理益处仍然不清楚.
研究的目的:
- 调查更年期和HRT对心理健康的影响.
- 检查更年期和HRT对认知功能的影响.
- 评估更年期和HRT对大脑结构的影响.
主要方法:
- 分析了来自约125,000名参与者的英国生物库数据.
- 评估更年期,HRT与心理健康,认知和大脑形态之间的关联.
- 专注于中叶 (MTL) 和前带皮层 (ACC) 中的灰质体积.
主要成果:
- 更年期与增加的焦虑,抑郁和睡眠问题相关.
- 使用HRT的女性报告的心理健康挑战比非HRT的绝经后女性更多.
- 绝经后的女性显示MTL和ACC灰质体积减少,HRT组的灰质体积最低.
结论:
- 更年期与不良的心理健康结果和灰色物质体积减少有关.
- HRT没有减轻这些影响,可能与更大的心理健康挑战有关,可能是由于基线差异.
- 研究结果强调了HRT的神经生物学影响以及在更年期期间需要心理健康支持.
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