在基于铜的金属有机框架的肝素功能化表面上吸附血氨酸
Zhenyu Gui1, Xiaoda Yang1, Hao Chen2
1College of Materials and Textile Engineering, Jiaxing University, Jiaxing, China.
概括
氨酸功能化的铜基金属有机框架 (CuMOFs-Hep) 有效地去除肌素,这是慢性病 (CKD) 的关键标志物. 这种新型吸附剂对血液净化有前途,并且具有改善的血红相容性.
科学领域:
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
背景情况:
- 肌素积累是慢性病 (CKD) 的一个重大问题,对患者的治疗结果产生负面影响.
- 开发有效的肌素去除方法对于改善CKD患者的生活质量至关重要.
研究的目的:
- 开发和表征氨酸功能化的铜基金属有机框架 (CuMOFs-Hep) 以提高肌素的去除.
- 评估开发的CuMOFs-Hep用于血液净化应用的血液兼容性和生物安全性.
主要方法:
- 使用APTES桥接,CuMOFs与肝素进行了合成和功能化.
- 鉴定包括XRD,SEM,FTIR,XPS和泽塔电位测量.
- 在模拟的CKD血清和患者血液中评估了肌素吸附,通过Cu2+浸出和血小板检测评估了生物安全性.
主要成果:
- 肝化显著增加了最大的肌素吸附能力,达到267.8mg/g,改善了68.7%.
- 观察到快速的肌素清除,在30分钟内消除65.9%,在2小时内达到75.0%.
- 在患者血液中,CuMOFs-Hep降低了80.9%的肌水平,同时显著降低了铜离子出和血小板激活.
结论:
- 在临床上相关的环境中,CuMOFs-Hep表现出高效和低泄漏的肌素吸附能力.
- 该材料表现出作为血液净化有效吸附剂的有希望的潜力,提供了更好的血液兼容性.
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