非吞的克拉衍生产品:危害公共健康的非法食补充剂
C Michael White1, Ava Sedensky1, Jordyn Belcourt1
1Department of Pharmacy Practice, University of Connecticut School of Pharmacy, Storrs, CT, USA.
Public health reports (Washington, D.C. : 1974)
|January 26, 2026
概括
包括vaping配方在内的非吞的kratom产品越来越多. 这些产品绕过正常的新陈代谢,缺乏安全数据,对消费者构成潜在风险.
科学领域:
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
- 监管科学 监管科学
背景情况:
- 1994年"食补充剂健康和教育法"规定,食补充剂必须被吞.
- 克拉 (Kratom) 源自Mitragyna speciosa树,传统上以粉末的形式食用.
- 新兴的非吞配方绕过了第一通代谢,改变了药理动力学特征.
研究的目的:
- 为了调查在非吞配方中的kratom衍生产品的可用性.
- 为了识别未吞的克拉产品的类型及其化学成分.
- 评估这些产品的营销和包装对未成年人的潜在吸引力.
主要方法:
- 调查了Kratom衍生产品的在线市场.
- 确定了49种不同的Kratom产品,这些产品以舌下条,口袋和vaping格式出售.
- 分析了产品中的化物,调味剂和同伴物质,如大麻大麻素.
主要成果:
- 67%的确定的kratom产品是vaping配方,其他产品是舌下条纹或口袋.
- 这些产品经常含有7-hydroxymitragynine和其他kratom类化合物,以及调味剂.
- 许多产品具有儿童吸引力的设计,缺乏儿童防护包装;一些vaping产品含有大麻大麻素.
结论:
- 非吞的kratom产品,特别是vaping类型,很普遍,并绕过第一通代谢.
- 这些新型配方缺乏安全性和药理动力学数据,需要消费者谨慎.
- 监管行动至关重要,以防止这些潜在不安全的kratom产品的销售.
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