周围血液炎症标志物与阻塞性睡眠呼吸暂停严重程度之间的相关性
Yingting Qi1, Tao Li1, Yi Zhao1
1Department of Otolaryngology Head and Neck Surgery, Peking University Third Hospital, Beijing, People's Republic of China.
概括
周围血液炎症标志物,如泛免疫炎症值 (PIV),可以帮助评估阻塞性睡眠呼吸暂停 (OSA) 的严重程度. 升高的PIV和SIRI表明严重的OSA,为改善临床风险分层提供了潜力.
科学领域:
- 生物标志物 生物标志物
- 炎症 炎症是一种炎症.
- 睡眠医学 睡眠医学
背景情况:
- 周围血液炎症指数提供了对全身炎症的非侵入性评估.
- 阻塞性睡眠呼吸暂停 (obstructive sleep apnea,简称OSA) 是一种在睡眠期间呼吸道反复阻塞的症状.
- 确定可靠的OSA严重性的生物标志物对于有效的临床风险分层至关重要.
研究的目的:
- 评估外周血液炎症标志物与OSA严重程度之间的关联.
- 为了确定OSA分类的预测生物标志物.
- 探索炎症标志物和软 palatal 的阻塞之间的相关性.
主要方法:
- 一项前性观察性研究,涉及266名成年人打.
- 计算炎症指数,包括泛免疫炎症值 (PIV),SIRI,SIL,中性粒细胞与淋巴细胞的比率,单细胞与淋巴细胞的比率 (MLR),以及血小板与淋巴细胞的比率.
- 通过呼吸暂停-呼吸暂停指数 (AHI) 和软 palatal阻塞通过米勒机动评估OSA的严重程度.
主要成果:
- 在严重的OSA病例中,PIV和SIRI显著升高 (分别P=.001和P=.012).
- PIV独立地与AHI严重程度相关 (OR=1.010,95% CI [1.003,1.017]).
- PIV和SIRI与AHI正相关 (r=.236和r=.218,两者的P<.001). MLR,PIV和SIRI水平随着软 palatal 崩的增加而增加.
结论:
- 全免疫炎症值 (PIV) 作为评估OSA严重程度的独立和可访问的生物标志物.
- 与单个标志物相比,PIV和SIRI等复合炎症指数可能提供更全面的全身炎症反映.
- 这些发现支持OSA表型和预后中复合炎症指数的实用性,可能补充临床评估.
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