中耳神经内分泌瘤:一系列案例突出了诊断和管理方面的挑战
Savannah Lukkes1, Ellise Minneker2, Oscar Velazquez Castro1
1University of California Davis School of Medicine, Sacramento, CA, USA.
The Annals of otology, rhinology, and laryngology
|January 26, 2026
概括
中耳神经内分泌瘤 (MeNETs) 是一种罕见的,低度的病变. 手术切除是必要的,通常需要修复手术,并且可能会出现延迟的复发,这凸显了长期随访的必要性.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 神经内分泌学神经内分泌学
- 在瘤学瘤学.
背景情况:
- 中耳神经内分泌瘤 (MeNETs) 是罕见的,可以模仿常见的耳朵病理.
- 尽管MeNET通常是惰的,但仍存在局部入侵和延迟复发的风险.
研究的目的:
- 描述MeNETs的表现,管理,组织病理学和长期结果.
- 扩大对这些罕见的中耳瘤的了解.
主要方法:
- 在两个三级医疗中心进行的回顾性病例系列.
- 参与了对5名经组织学确认的MeNETs患者的图表审查.
- 用血素和欧染色和免疫组织化学用于他的病理学评估.
主要成果:
- 患者表现出单侧耳朵症状;成像显示中耳朵质量,有时带有骨侵蚀.
- 所有患者都需要 tympanomastoidectomy 和至少一个额外的手术残留或复发性疾病.
- 组织病理学证实了低度的神经内分泌瘤;两名患者经历了手术后的局部复发延迟.
结论:
- MeNETs是罕见的,低级瘤经常被误诊为其他中耳病变.
- 手术切除是主要的治疗方法,经常需要修复手术.
- 预后有利,但延迟复发的可能性需要长期的随访和考虑第二次检查程序.
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