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细胞间自组合的机械力驱动球形状的形成

Honglei Lu¹, Yaoting Li¹, Xuejiao Yang¹

¹Department of Chemistry, School of Science, Westlake University, No. 600 Dunyu Road, Hangzhou, Zhejiang Province, 310024, China.

Nature communications

|January 26, 2026

概括

科学家们使用类纳米纤维设计了具有毛细血管状结构的3D细胞球体. 这种组织工程的进步改善了癌症和糖尿病研究的模型,提高了药物输送和再生医学的潜力.

科学领域:

生物材料科学生物材料科学
组织工程是组织工程.
细胞生物学细胞生物学

背景情况:

细胞球体对于建模组织生理学和疾病至关重要.
目前的模型往往缺乏在本地组织中看到的复杂血管化.
在球形体中设计血管类结构是再生医学的一个关键挑战.

研究的目的:

开发一个工程细胞球体具有毛细管状结构的一般策略.
调查纳米纤维在诱导组织形态发生和功能中的作用.
为癌症和糖尿病研究创建先进的3D模型.

主要方法:

利用纳米纤维的细胞间自我组装来设计细胞球体.
通过纳米纤维材料诱导细胞外基质 (ECM) 中的机械变化.
激活机械转导通路以增强细胞形态发生.
分析基因表达特征和功能性检测 (例如胰岛素分泌).

主要成果:

成功设计了具有集成毛细管状结构的动态3D球体.
在工程化球形体内,证明了增强的细胞-细胞和细胞-矩阵相互作用.
瘤球状体表现出基因表达特征,反映出患者衍生的瘤.
岛屿细胞球体显著增加功能,包括葡萄糖刺激的胰岛素分泌.

结论:

基于酸纳米纤维的自我组装为创建血管化的3D细胞模型提供了一个强大的平台.
工程球体非常模仿人类组织生理学,为疾病研究提供了卓越的模型.
这种方法在推进癌症治疗,药物输送和再生医学应用方面具有重大潜力,特别是在糖尿病治疗方面.

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