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Updated: Jan 28, 2026

Retroviral Overexpression of CXCR4 on Murine B-1a Cells and Adoptive Transfer for Targeted B-1a Cell Migration to the Bone Marrow and IgM Production
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Published on: May 31, 2020

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在CAR-T细胞中,CXCR4诱导记忆形成而不是消耗,以实现持久的白血病向向

Ari Itoh-Nakadai1,2, Minggao Liang1,3,4, Michiho Shindo1

  • 1Laboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, RIKEN, Kanagawa, Japan.

Nature communications
|January 26, 2026
PubMed
概括

工程化学抗原受体 (CAR) -T细胞表达CXCR4提高了它们在急性髓性白血病 (AML) 中的持久性和抗白血病活性. 这一策略增强了CAR-T细胞的记忆和耐用性,为AML免疫疗法提供了一种有前途的方法.

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