一个磁性驱动的机器人囊内镜用于现场可视化和微针介导的向药物输送到胃肠道
Weiyuan Chen1,2, Jianbo Sui3, Xiaobiao Cao1
1State Key Laboratory for High Performance Tools, Guangdong Provincial Key Laboratory of Minimally Invasive Surgical Instruments and Manufacturing Technology, School of Electromechanical Engineering, Guangdong University of Technology, Guangzhou, China.
Microsystems & nanoengineering
|January 26, 2026
概括
这项研究引入了磁性驱动的机器人囊内镜 (MARCE),用于综合性胃肠道诊断和治疗. 马尔斯可以实现向的药物输送和精确的导航,改善患者的治疗.
科学领域:
- 生物医学工程 生物医学工程
- 胃肠病学 胃肠病学
- 机器人技术 机器人技术 机器人技术
背景情况:
- 囊内镜彻底改变了胃肠道诊断,但缺乏治疗能力,往往需要侵入性手术.
- 目前的诊断工具需要单独的治疗干预,在检测和治疗之间造成差距.
研究的目的:
- 开发一个磁性驱动的机器人囊内镜 (MARCE),整合诊断和向治疗.
- 为了弥合胃肠道诊断和治疗之间的差距,使用一个单一的,微创设备.
主要方法:
- 马尔斯包括一个可伸缩的微型摄像头,用于药物输送的双层微针贴片,以及一个电热保护罩.
- 一个定制的电磁驱动系统可以实现精确的3D运动和微针透.
- 活体猪肠道组织被用于评估MARCE的运动,药物释放和治疗输送能力.
主要成果:
- 马尔克证明了受控的上腺素释放 (高达0.4毫克) 和足够的力量用于肠道运动和透.
- 实现了精确的3D运动,位置误差小于1.5毫米,并控制了微针穿透率 (0.15N峰值力).
- 在ex-vivo猪肠道组织中成功将药物输送到多种病变中得到证实.
结论:
- 马尔斯平台成功地集成了磁导航,实时可视化和针对胃肠道疾病的向药物输送.
- 这种机器人囊为胃肠道出血和其他疾病提供了一种简化,最少侵入性的解决方案,提高了患者的舒适度和治疗精度.
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