基因表达进化的重复性在实验环境适应中的进化
Jiachen Li1,2, Jianzhi Zhang3
1Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Nature communications
|January 26, 2026
概括
进化适应具有惊人的可重复性. 实验室实验表明,基因表达在复制种群中可预测地发生变化,由环境特异性选择驱动,而不仅仅是偶然.
科学领域:
- 进化生物学是进化的生物学.
- 基因组学就是基因组学.
- 分子生物学分子生物学
背景情况:
- 了解进化中偶然与必然之间的平衡是一个关键问题.
- 实验室进化研究提供了一个可控的环境来研究进化的重复性.
研究的目的:
- 评估基因表达进化在多种物种和环境中的可重复性.
- 为了确定环境选择在多大程度上推动基因表达的可预测的进化变化.
主要方法:
- 分析了来自10个实验室进化研究中的转录组数据,涉及6种物种 (1种 prokaryotic, 5种 eukaryotic).
- 在22个不同的环境中检查了182,103种基因表达特征.
- 复制进化的比较,在相同的与不同的环境和突变积累实验.
主要成果:
- 基因表达进化表现出高重复性,超过10-100个标准偏差的机会预期.
- 表达进化中的一致性主要是由环境特异性选择驱动的.
- 由更多转录因子调节的基因表现出更可重复的表达进化.
结论:
- 现型进化,特别是基因表达,在环境适应过程中具有高度的重复性和决定性.
- 这与基因型进化的往往不可重复的性质形成鲜明对比.
- 环境特异性选择在塑造可预测的进化轨迹方面发挥着至关重要的作用.
相关概念视频
What is Gene Expression?
196.4K
Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
196.4K
Genome Size and the Evolution of New Genes
9.1K
While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
9.1K
Genome Size and the Evolution of New Genes
3.4K
3.4K
Gene Evolution - Fast or Slow?
8.2K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
In contrast, regions which code...
8.2K
Gene Evolution - Fast or Slow?
3.6K
3.6K
Cell Specific Gene Expression
16.5K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
16.5K


