预测不可预测的:在瘤学中FAPI-PET成像的预后和预测能力:系统性审查和元分析
Sajjad Sadeghpour1, Atena Aghaee1, Saba Sadeghpour2
1Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
European journal of nuclear medicine and molecular imaging
|January 26, 2026
概括
基线纤维细胞激活蛋白抑制剂 (FAPI) 基PET扫描准确预测癌症存活率. 较高的FAPI吸收值 (SUVmax,MTV,TLFAPI) 表示整体存活率 (OS) 和无进展存活率 (PFS) 较差.
科学领域:
- 在瘤学瘤学.
- 核医学是一种核医学.
- 无线电学 (Radiomics) 是一种辐射学.
背景情况:
- 基于纤维细胞激活蛋白抑制剂 (FAPI) 的正子发射断层扫描 (PET) 成像准瘤侧膜.
- 准确预测患者的结果对于有效的癌症管理至关重要.
研究的目的:
- 系统地审查基线FAPI-PET扫描在预测整体生存 (OS),无进展生存 (PFS) 和治疗响应方面的准确性.
- 评估FAPI-PET参数在各种癌症类型中的预后和预测价值.
主要方法:
- 在PubMed和Cochrane图书馆进行系统的文献搜索,直到2025年8月.
- 包括评估FAPI-PET参数对OS,PFS和治疗反应的预后和预测价值的研究.
- 对关键FAPI-PET参数的聚合危险比率 (HR) 的元分析.
主要成果:
- 分析了47篇出版物,其中包括1430名不同癌症类型的患者.
- 较高的最大标准化吸收值 (SUVmax) 与较差的生存状况 (HR: 2.36) 和PFS (HR: 1.88) 有显著的关联.
- 增加的FAPI活跃瘤体积 (MTV) (OS HR: 3.33,PFS HR: 2.42) 和总损伤FAP表达 (TLFAPI) (OS HR: 3.35,PFS HR: 2.45) 也与更糟糕的结果有关.
结论:
- 基线FAPI-PET参数,包括MTV,SUVmax和TLFAPI,作为癌症患者的OS和PFS可靠的预后标志物.
- FAPI-PET对瘤层的成像提供了有价值的预后信息.
- FAPI吸收参数与治疗结果相关,并在治疗后发生变化.
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