看似健康的成年人血压和功能下降:德黑兰脂质和葡萄糖研究
Navid Ebrahimi1, Soroush Masrouri1, Shakiba Fardoost1
1Prevention of Metabolic Disorders Research Center, Research Institute for Metabolic and Obesity Disorders, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
血压升高,即使在正常范围内,也会增加健康成年人功能下降 (RFD) 的风险. 较高的透析血压 (DBP) 是RFD的显著预测因素,独立于缩血压 (SBP).
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 心脏病学 心脏病学
- 公共卫生 公共卫生
背景情况:
- 心血管健康与功能密切相关.
- 了解功能衰退 (RFD) 的早期风险因素对于预防策略至关重要.
- 在没有传统心脏代谢风险因素的人群中,血压 (BP) 对RFD的影响需要进一步调查.
研究的目的:
- 调查血压 (BP) 水平与功能下降 (RFD) 之间的关联.
- 检查压缩性血压 (SBP) 和压缩性血压 (DBP) 对RFD的独立贡献.
- 为了评估这一关联,在一组具有保存功能且没有心血管疾病或其他主要风险因素的个体中进行评估.
主要方法:
- 一项纵向研究跟踪了3455名功能维护的参与者 (eGFR≥60毫升/分钟/1.73米2).
- 参与者没有心血管疾病,高血压,糖尿病,失脂症和吸烟.
- 功能下降 (RFD) 被定义为eGFR<60毫升/分钟/1.73米2,与基线相比下降≥30%.
- 多变量考克斯回归模型分析了BP类别/增加和RFD风险之间的关联.
主要成果:
- 每增加10 mmHg的SBP和增加5 mmHg的DBP最初都与更高的RFD风险有关.
- 当包括SBP和DBP时,只有DBP仍然与RFD风险增加有显著的关联 (HR 1.19).
- 这种DBP和RFD之间的关联甚至在BP<120/80mmHg的个体中也存在,每增加5mmHg的DBP风险增加29%.
结论:
- 高血压水平,即使在正常范围内,也与功能下降的风险增加有关.
- 扩张性血压是没有传统心脏代谢风险因素的个体中RFD的显著独立预测因素.
- 这些发现强调了血压控制对脏健康的重要性,即使在看似健康的人群中也是如此.
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