在对犬类垂体瘤进行绝对意图分离放射治疗后的耐受性和有效性
Silvia Caeiro1, Nicholas Goody1, Juan Carlos Serra1
1The Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Edinburgh, UK.
概括
针对犬类垂体瘤 (PTs) 的常规分离放射治疗 (CFRT) 显示出持久的瘤控制和很少的不良事件. 建议定期监测治疗后的低上皮质症,以改善狗的健康结果.
科学领域:
- 兽医瘤学 兽医瘤学
- 辐射瘤学 辐射瘤学
- 狗医疗 狗医疗 狗医疗
背景情况:
- 传统分离放射疗法 (CFRT) 是对犬类垂体瘤 (PTs) 的常见治疗方法.
- 有限的数据存在于长期的结果和成像响应CFRT在PTs的狗.
研究的目的:
- 评估PTS的狗中CFRT的长期结果和成像反应.
- 为了确定与狗PT治疗结果相关的预后因素.
主要方法:
- 对29只以50 Gy CFRT (20 分数 × 2.5 Gy) 治疗的PT犬的医疗记录进行了回顾性审查.
- 对预后因素的分析,包括年龄,性别,神经症状,内分泌异常和瘤大小.
- 使用RECIST标准评估瘤反应;使用Cox比例危险模型分析生存率.
主要成果:
- 在14只随访成像的狗中,在64.3%的狗中观察到部分反应,在35.7%的狗中观察到稳定的疾病.
- 无进展生存时间的中位数是523天;所有原因的生存时间的中位数是669天.
- 高 adrenocorticism 与生存率降低有关 (p=0.02); 低 adrenocorticism 在两只狗中发生.
结论:
- 50Gy的CFRT在2.5Gy分数中提供了对狗PTs的持久瘤控制,具有可管理的不良事件概况.
- 长期随访显示,在某些情况下,瘤持续减少.
- 对于狗患者来说,对RT后的低 adrenocorticism 的监测至关重要.
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