用肉毒神经毒素治疗的脑儿童的上肢运动范围:基于人口的队列研究
Jenny Hedberg-Graff1,2, Fredrik Granström3, Marianne Arner4,5
1Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
BMC musculoskeletal disorders
|January 26, 2026
概括
早期的肉毒神经毒素-A (BoNT-A) 治疗可能会改善脑 (CP) 儿童的被动运动范围 (pROM). 这项研究发现,早期干预与随着时间的推移更好的上肢pROM结果有关,可能会预防合.
科学领域:
- 儿科康复儿童康复中心
- 神经肌肉疾病 神经肌肉疾病
- 生物机械分析 生物机械分析
背景情况:
- 患有脑 (CP) 的儿童通常会在上肢的被动运动范围 (pROM) 发生变化.
- 收缩可以在成长过程中发展,影响运动功能.
- 神经毒素-A (BoNT-A) 用于CP管理,但其对pROM的长期影响需要进一步调查.
研究的目的:
- 为了研究CP的儿童上肢pROM随时间变化的变化.
- 为了比较使用BoNT-A治疗和不治疗的儿童之间的pROM结果.
- 评估早期与晚期BoNT-A治疗对pROM的影响.
主要方法:
- 从2000年至2017年,对瑞典脑麻随访计划和注册表 (CPUP) 的数据进行了回顾性分析.
- 包括患有性或动力障碍的儿童,年龄为1-15岁.
- 使用混合模型分析五个上肢运动的pROM变化.
主要成果:
- 该研究包括496名患有CP的儿童;22%接受了BoNT-A治疗.
- 大约36%的人在15岁之前就出现了上肢收缩.
- 早期的BoNT-A治疗 (在4岁之前) 与较晚的治疗相比,与更好的pROM结果有关.
结论:
- 上肢收缩是一个重大问题,影响了三分之一的儿童在成长过程中患有CP.
- 定期监测pROM可以识别肌肉缩短的早期迹象.
- 早期的BoNT-A干预表明有助于在患有CP的儿童中维持上肢pROM的承诺.
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