结构性核磁共振图像在意义障碍性的狗的乳头,尾状核和乳头间粘附的差异
Tsz Yan Chan1, Nicolas Israeliantz1, Megan Madden1
1Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK.
概括
与健康狗相比,患有异常性 (IE) 的狗表现出显著的结构性大脑变化,包括较大的thalamic粘附和较小的thalamus和尾状核体积. 需要进一步的研究来理解这些狗的发现.
科学领域:
- 兽医神经学 兽医神经学
- 进行比较的神经成像.
- 的研究研究.
背景情况:
- 在人类中,已知和基底核 (BN) 的结构变化.
- 有限的研究存在于具有特异性 (IE) 的狗中类似的变化.
研究的目的:
- 评估和比较与IE对照狗的乳头和尾状核形态.
- 为了研究狗的潜在结构差异.
主要方法:
- 对磁共振成像 (MRI) 研究的回顾性分析.
- 在IE (n=40) 和对照组 (n=38) 之间比较thalamic间粘附 (ITA) 厚度/面积,thalamic面积/体积和尾状核面积/体积.
主要成果:
- 患有IE的狗具有显著更大的ITA厚度和面积.
- 患有IE的狗表现出较小的胸膜面积和体积,以及较小的尾状核体积.
- 在尾状核区域或 thalamus 和尾状核的不对称指数中没有发现显著差异.
结论:
- 较小的甲状腺和尾状腺核大小与犬类异常性有关.
- 需要进一步的研究,以将发现推广到其他基底核,并探索IE病理生理学中的电路参与.
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