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月经周期温度动力学及其与受孕的关联:人内和人间分析
Orsolya Kiss1, Marie Gombert-Labedens1, Alan Taitz2
1Bioscience Division, SRI International, Menlo Park, California, USA.
Journal of biological rhythms
|January 27, 2026
概括
对月经温度节律的详细分析表明,这些周期的强度 (幅度) 和时间 (阶段) 都与受孕概率有关. 最佳受孕发生在强烈的,恰到好处的温度节奏与肥沃窗口保持一致时,特别是在典型的周期长度中.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 时间生物学 时间生物学
- 生育能力研究 生育能力研究
背景情况:
- 月经周期温度调节受到生殖荷尔蒙的影响,尤其是孕激素.
- 基本体温跟踪用于排卵检测,但详细的节律特征对怀孕的影响不太清楚.
- 周期长度和年龄的个体变化可以影响温度模式和受孕概率.
研究的目的:
- 调查月经温度节律特征 (幅度,阶段) 与受孕概率之间的关联.
- 用人间和人内研究设计来分析这些关联.
- 为了考虑到周期长度和年龄的个体变化.
主要方法:
- 分析了来自"Fertili"数据集的4682个月经周期的423名女性 (19-40岁) 的每日温度数据.
- 循环级温度波动的建模,使用带有循环项的通用线性混合效应模型 (GLMM) 来推导振幅和相位.
- 在人体内比较预怀孕和非怀孕周期,重点关注在肥沃窗口期间发生性交的周期.
主要成果:
- 在周期间的月经温度中观察到一个强大的振荡模式.
- 更高的平均温度和有利的阶段时间与更高的受孕概率有关,特别是在更长的周期中.
- 在较短的周期 (≤35天) 中,怀孕的可能性最高,其幅度高,相位及时;在较长的周期中,相位时间更为关键.
结论:
- 月经温度节律的大小 (幅度) 和时间 (阶段) 都提供了除了简单的卵巢后升高检测之外,关于怀孕潜力的信息.
- 最佳受孕概率与与肥沃窗口保持一致的强烈,及时的温度节奏有关,特别是在典型的周期长度中.
- 这些发现增强了对生育指标的理解,超出了传统的基本体温跟踪.
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