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Updated: Jan 28, 2026

Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling
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反应性代谢物和共价结合对药物候选物选择的相关性

Jack Uetrecht

    Drug metabolism reviews
    |January 27, 2026
    PubMed
    概括

    异常药物反应 (IDRs) 通常是免疫介导的. 识别风险因素,如损伤相关的分子模式分子 (DAMP) 和抗原呈现细胞 (APC) 激活,可能会比传统的共价结合研究更好地进行预测.

    关键词:
    CD8 T 细胞 CD8 T 细胞一种共价结合的结合.与损伤相关的分子模式分子分子.奇特的同步药物反应.奇特的药物诱导性肝损伤.免疫介导的药物不良反应.反应性代谢物是反应性代谢物.

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