在多发性骨髓瘤的黑人和白人老年人中开始治疗:A SEER-Medicare分析
Matthew R LeBlanc1,2, Xi Zhou2, Christopher D Baggett2,3
1School of Nursing, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Cancer medicine
|January 27, 2026
概括
多发性骨髓瘤 (MM) 的黑人患者比白人患者晚开始治疗. 尽管如此,随着时间的推移,MM治疗开始的种族差异仍然保持不变,而不是像假设的那样增加.
科学领域:
- 在瘤学瘤学.
- 健康差距 研究 研究 研究 研究
- 老年医学 老年医学
背景情况:
- 调查癌症护理中的种族差异对于公平的健康结果至关重要.
- 多发性骨髓瘤 (MM) 不成比例地影响老年人,强调需要检查这个人口群中的治疗开始模式.
研究的目的:
- 描述和比较黑人和白人老年人诊断出多发性骨髓瘤 (MM) 开始治疗的时间.
- 为了确定MM治疗开始的种族差异是否随着时间的推移而扩大.
主要方法:
- 利用SEER-Medicare数据库来识别2007年至2017年间被诊断患有MM的65岁以上的黑人和白人患者.
- 采用了考克斯的比例危险模型来分析三个不同的诊断时期 (2007-10,2011-14,2015-17) 开始治疗的时间.
- 诊断后3个月,6个月和12个月治疗开始的估计累计发病率.
主要成果:
- 与黑人MM患者相比,白色MM患者在所有研究期间 (HRs从1.35到1.36) 开始治疗的可能性要大得多.
- 在3,6个月和12个月后,在治疗开始的累积发病率中观察到显著和持久的黑/白差异.
- 与假设相反,MM治疗开始的黑人/白人差异并没有随着时间的推移而增加.
结论:
- 与白人患者相比,MM的黑人患者晚些时候开始治疗,并且在整体上开始治疗的可能性较小.
- 观察到的多发性骨髓瘤治疗启动的种族差异在2007年至2017年期间保持不变,这与差异增加的预期相反.
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