原子精确的Au18集群用于NIR-II精确的肝脏缺血-再输液3D可视化
Zhenhua Li1, Zili Zhang2, Siyu Ao3
1Department of Physics and Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, School of Sciences, Tianjin University, Tianjin, China.
Advanced healthcare materials
|January 27, 2026
概括
原子精确的黄金集群提供了增强的第二近红外 (NIR-II) 生物成像. 用 (Au17Zn1) 兴奋黄金集群显著提高光和稳定性,可视化小鼠肝损伤.
科学领域:
- 纳米材料科学 科学 纳米材料科学
- 生物医学成像技术 生物医学成像技术
- 量子化学 是一个量子化学.
背景情况:
- 传统的光成像在组织透和信号对噪声比率上受到限制,这是由于散射和自光.
- 第二个近红外 (NIR-II) 窗口 (1000-3000 nm) 提供更深的组织透和更好的信号质量.
- 原子精确的黄金星团正在成为有希望的探测器,以提高NIR-II发射,因为它们的可调节结构.
研究的目的:
- 为先进的NIR-II生物成像应用设计可控制的黄金集群.
- 为了研究单个原子兴奋剂对Au18集群的光学特性和稳定性的影响.
- 评估开发的探针可用于可视化肝脏缺血-再输损伤 (HIRI) 的潜力.
主要方法:
- 原子精确金 (Au18) 的合成和表征.
- 用单个原子对Au18集群进行兴奋剂,以形成Au17Zn1集群.
- 评估光学特性 (光增强,光稳定性) 和生物相容性.
- 使用光片显微镜 (LSM) 用HIRI对小鼠肝脏组织的体内生物成像.
主要成果:
- 与未使用药物的群体相比,Au17Zn1群体的NIR-II光度增强了4.1倍.
- 兴奋剂优化了光学特性,提高了亮度和光稳定性,同时保持了卓越的生物安全性.
- 在HIRI小鼠模型中,3D LSM成像清楚地界定了血管变化 (120-300微米扩张),可视化了损伤进展.
结论:
- 用Zn合的Au17Zn1集群代表了一个高效和稳定的NIR-II光探针.
- 开发的探测器显示出对肝损伤的敏感和高分辨率可视化具有重大潜力.
- Au17Zn1提供了一个有前途的工具,用于评估和研究肝脏缺血-再输液损伤.
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