艾滋病毒相关恶性瘤的变化:土耳其也是如此吗?
Yıldız Olçar1, Alper Gündüz2, Dilek Yıldız Sevgi3
1Department of Infectious Diseases and Clinical Microbiology, Sancaktepe Şehit Prof Dr. İlhan Varank Training and Research Hospital, University of Health Sciences, Istanbul, Türkiye.
Current HIV research
|January 27, 2026
概括
癌症仍然是艾滋病毒感染者 (PLWH) 的重要关注点. 在艾滋病毒诊断和随访期间进行早期癌症查对于管理抗逆转录病毒治疗 (ART) 的PLWH癌症风险增加至关重要.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 癌症是艾滋病毒感染者 (PLWH) 死亡的主要原因.
- 抗逆转录病毒疗法 (ART) 增加了PLWH的预期寿命,但也增加了癌症风险.
- 了解PLWH中的癌症发病率,流行率和死亡率至关重要.
研究的目的:
- 确定艾滋病定义癌症 (ADC) 和非艾滋病定义癌症 (NADC) 在PLWH的发病率,流行率和死亡率.
- 分析PLWH队列中的癌症类型和随时间的变化趋势.
- 为PLWH的癌症查和预防策略提供信息.
主要方法:
- 在土耳其伊斯坦布尔进行了回顾性,横截面研究.
- 对2011年1月至2019年12月期间被诊断出患有癌症的艾滋病毒/艾滋病患者的分析.
- 研究期间分为三年间隔,以评估癌症类型的变化.
主要成果:
- 在1438名PLWH中,3.9%的患者被诊断出癌症.
- 癌症患者在艾滋病毒诊断时的平均年龄更高,艾滋病毒RNA水平更高,CD4+ T淋巴细胞数量更低.
- 艾滋病确定的癌症 (ADCs) 的同时诊断率高 (72%);卡波西肉瘤是最常见的 (71.8%).
- 霍奇金淋巴瘤和肺癌是最常见的非艾滋病定义癌症 (NADC).
结论:
- 艾滋病确定的癌症仍然是土耳其PLWH的重大临床问题.
- 在PLWH中增加癌症风险需要考虑年龄,性别和免疫状况的国家查指南.
- 在艾滋病毒诊断和日常随访期间整合癌症查对于有效的管理至关重要.
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