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Mary T Caserta1, Thomas J Mariani1, Edward E Walsh2

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婴儿的呼吸道同胞性病毒 (RSV) 感染与反复的喘息有关. 在RSV感染期间鼻腔基因表达可以预测婴儿未来的复发性喘息.

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这就是为什么RSV RSV.不同表达的基因 (DEG)基因表达特征 基因表达特征这就是iGRSSSS的意义.甲基基因组 (metagenome) 是一个基因组.微生物组是一个微生物组.经常发生的喘息.

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科学领域:

  • 儿童传染病 儿童传染病
  • 呼吸系统医学 呼吸系统医学
  • 微生物组研究 微生物组研究
  • 免疫学 免疫学 免疫学

背景情况:

  • 呼吸道同胞病毒 (RSV) 是婴儿住院的主要原因.
  • 患有RSV疾病的婴儿患有复发性喘息的可能性增加.
  • 了解影响RSV严重程度和长期呼吸道结果的因素至关重要.

研究的目的:

  • 在急性RSV感染期间调查鼻气道基因表达和微生物组合之间的关联.
  • 为了将这些发现与呼吸系统疾病的严重程度和婴儿复发性喘息的发展相关联.
  • 确定潜在的生物标志物来预测RSV感染后的复发性喘息.

主要方法:

  • 确认RSV感染的以前健康的婴儿的未来招生 (2019-2023年).
  • 收集用于元基因组和转录基因组测序的鼻子拭子和洗.
  • 使用改进的全球呼吸系统严重性评分 (iGRSS) 评估疾病严重程度,并对复发性喘息进行1年的随访.
  • 应用多变量回归模型来分析基因表达和微生物群数据.

主要成果:

  • 405个基因与疾病严重程度有显著的关联,特别是那些在先天性免疫和相互作用蛋白信号通路中的基因.
  • 鼻子微生物组组成显示了与严重程度的关联:Dolosigranulum反向和Haemophilus与iGRSS直接相关.
  • 在急性RSV感染期间,鼻腔基因表达精确预测了复发性喘息 (交叉验证的AUC=0.882),超过了微生物组数据.

结论:

  • 在初级RSV感染期间,鼻腔基因表达和微生物组概况与急性疾病严重程度和复发性喘息有关.
  • 在RSV感染期间,鼻气道中的宿主转录特征作为后续复发性喘息的预测标记.
  • 这项研究强调了宿主基因表达的潜力,作为RSV后婴儿长期呼吸系统结果的预测工具.