关于DESCIDE-RD的协议:确定共享决策在类风湿性疾病药物治疗选择中的有效性
Se Rim Choi1,2, Soo-Kyung Cho1,2, Bora Nam1,2
1Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea.
Journal of Korean medical science
|January 27, 2026
概括
本研究将结构化共享决策 (SDM) 模型与选择生物药物或氏激酶 (JAK) 抑制剂的风湿性关节炎 (RA) 或结性脊髓炎 (AS) 患者的标准护理进行比较.
科学领域:
- 类风湿病学 类风湿病学
- 医疗保健服务研究 医疗服务研究
- 临床试验方法论 临床试验方法论
背景情况:
- 生物药物和简氏激酶 (JAK) 抑制剂为风湿性疾病提供了扩展的治疗选择.
- 国际指导方针主张在治疗选择中进行共享决策 (SDM).
- 在类风湿性关节炎 (RA) 和结性脊柱炎 (AS) 的治疗决策中,最佳的患者参与至关重要.
研究的目的:
- 评估结构化的SDM模型是否能改善患者对SDM的看法,与标准护理相比.
- 在SDM模型中评估决策辅助和AI聊天机器人的影响.
- 在RA和AS患者中比较生物药物和JAK抑制剂的治疗选择过程.
主要方法:
- 一个开放的,多中心的,分层的集群随机化试验,涉及300名RA或AS患者.
- 三个部门:SDM组I (三谈模式+决策辅助工具),SDM组II (三谈模式+决策辅助工具+AI聊天机器人) 和标准护理.
- 主要结果:共享决策问卷得分;次要结果:决策冲突量表,健康赋权量表,利兹满意度问卷,EuroQol-5维度.
主要成果:
- 该研究旨在提供关于结构化SDM有效性的证据.
- 它将在不同SDM干预组和标准护理中比较患者的感知和结果.
- 通过iCReaT收集数据.
结论:
- 结构化的SDM模型,可能通过数字工具来增强,可以改善患者参与选择RA和AS的先进疗法.
- 这些发现可以为临床实践提供信息,并改善风湿病患者的治疗结果.
- 这项研究解决了在复杂的治疗场景中基于证据的SDM实施的需要.
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