口服抗生素治疗肩围假肢关节感染:当前和不断发展的概念
Christopher Fernainy1, Amritpal S Randhawa2, Matthew Frederickson2
1University of Nevada Reno School of Medicine, Reno, Nevada.
JB & JS open access
|January 27, 2026
概括
口服抗生素在治疗肩膀周围假肢关节感染 (PJI) 中表现有前途,为静脉注射 (IV) 抗生素提供了一个潜在的不那么繁重的替代方案. 需要进一步的高质量试验来证实肩部PJI的这些发现.
科学领域:
- 整形外科手术 整形外科手术
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 肩部周围假肢关节感染 (PJI) 的常规治疗包括通过外围插入的中央 (PICC) 线进行长时间的静脉注射 (IV) 抗生素.
- 这种传统方法带有风险,包括与导管相关的感染,延长住院时间和增加医疗保健成本.
- 最近的证据,包括OVIVA试验,表明口服抗生素在复杂的骨科感染中可能与静脉注射抗生素一样有效.
研究的目的:
- 评估越来越多的关于使用口服抗生素治疗肩膀PJI的证据.
- 评估口服抗生素治疗作为IV抗生素替代品在治疗肩膀PJI中的潜力.
- 突出进一步研究的需要,以确认口服抗生素在肩膀PJI中的有效性和安全性.
主要方法:
- 审查当前文献和新兴的关于肩膀PJI口服抗生素治疗的研究.
- 对现有数据的分析,承认大多数研究都是小的和追溯的.
- 考虑OVIVA等关于复杂骨科感染的试验结果.
主要成果:
- 有限但越来越多的数据表明,口服抗生素治疗可能对特定患者的肩膀PJI有效.
- 现有研究表明,口服抗生素治疗方案可能有令人满意的结果.
- 目前的证据库主要由小型的回顾性调查组成.
结论:
- 口服抗生素治疗为管理肩膀PJI提供了一个有希望的替代方案.
- 早期证据支持特定患者队列的令人满意的结果.
- 高质量的多中心试验至关重要,以确定口服抗生素对肩膀PJI的有效性和安全性.
相关概念视频
Muscles of the Shoulder
9.1K
The muscles surrounding the shoulder girdle, including the clavicle and scapula, primarily stabilize the scapula. This stable base allows other muscles to move the humerus effectively. Scapular movements often mirror those of the humerus and extend its range of motion. For instance, raising the arm above the head would not be feasible without simultaneous upward rotation of the scapula.
Anterior Thoracic Muscles
The anterior thoracic muscles include the serratus anterior, subclavius, and...
Anterior Thoracic Muscles
The anterior thoracic muscles include the serratus anterior, subclavius, and...
9.1K
Antibiotic Selection
59.9K
Overview
59.9K
Structural Joints: Synovial Joints
6.7K
Synovial joints are the most common type of joint in the body. A key structural characteristic for a synovial joint is the presence of a joint cavity. This fluid-filled space is where the articulating surfaces of the bones contact each other. Also, unlike fibrous or cartilaginous joints, the articulating bone surfaces at a synovial joint are not directly connected to each other with fibrous connective tissue or cartilage. This gives the bones of a synovial joint the ability to move smoothly...
6.7K
Structural Joints: Fibrous Joints
3.7K
Fibrous joints are a type of joint where the bones are connected by fibrous connective tissue. These joints provide stability and minimal to no movement between the articulating bones. There are three types of fibrous joints.
Suture
All the bones of the skull, except for the mandible, are joined to each other by a fibrous joint called a suture. The fibrous connective tissue found at a suture strongly unites the adjacent skull bones and thus helps to protect the brain and form the face. In...
Suture
All the bones of the skull, except for the mandible, are joined to each other by a fibrous joint called a suture. The fibrous connective tissue found at a suture strongly unites the adjacent skull bones and thus helps to protect the brain and form the face. In...
3.7K
Structural Joints: Cartilaginous Joints
4.0K
As the name indicates, at a cartilaginous joint, the adjacent bones are united by cartilage, a tough but flexible type of connective tissue. Unlike synovial joints, these types of joints lack a joint cavity and involve bones joined together by either hyaline cartilage or fibrocartilage.
There are two types of cartilaginous joints:
Synchondrosis
A synchondrosis ("joined by cartilage") is a cartilaginous joint where bones are connected by hyaline cartilage. Synchondrosis may be temporary...
There are two types of cartilaginous joints:
Synchondrosis
A synchondrosis ("joined by cartilage") is a cartilaginous joint where bones are connected by hyaline cartilage. Synchondrosis may be temporary...
4.0K
Joints
35.6K
Joints, also called articulations or articular surfaces, are points at which ligaments or other tissues connect adjacent bones. Joints permit movement and stability, and can be classified based on their structure or function.
Structural joint classifications are based on the material that makes up the joint as well as whether or not the joint contains a space between the bones. Joints are structurally classified as fibrous, cartilaginous, or synovial.
Fibrous Joints Are Immovable
The bones of a...
Structural joint classifications are based on the material that makes up the joint as well as whether or not the joint contains a space between the bones. Joints are structurally classified as fibrous, cartilaginous, or synovial.
Fibrous Joints Are Immovable
The bones of a...
35.6K


