[关于表皮粘膜屏障损伤导致慢性鼻炎的研究进展]
Haosu Huang1, Shouming Cao1, Haiying Wu1
1Department of Otorhinolaryngology，the 2nd Affiliated Hospital of Kunming Medical University，Kunming，651006，China.
概括
慢性鼻炎 (CRS) 涉及持续的鼻炎,影响生活质量. 本综述探讨了CRS中的上皮屏障功能障碍,突出了针对性治疗的机制.
科学领域:
- 免疫学 免疫学 免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 细胞生物学 细胞生物学
背景情况:
- 慢性鼻炎 (CRS) 是一种普遍的疾病,其特征是鼻粘膜的炎症持续超过12周.
- CRS显著降低了患者的生活质量,并给医疗保健系统带来了巨大的经济负担.
- 目前的研究越来越多地关注表皮屏障作为CRS病理生理学的中心因素,超越了简单的机械阻塞模型.
研究的目的:
- 系统地审查CRS中鼻上皮质的结构变化.
- 阐明关键的分子机制,有助于表皮屏障分解在CRS.
- 为开发针对CRS上皮质屏障的新疗法提供理论基础.
主要方法:
- 对研究CRS病理生理学的研究进行系统文献综述.
- 对表皮屏障功能,免疫失调和CRS细胞异常的研究进行分析.
- 检查分子机制,包括细胞因子失衡,上皮层-介质细胞过渡 (EMT) 和紧密结节破坏.
主要成果:
- CRS与鼻上皮的显著结构变化有关.
- 多种因素导致表皮屏障功能障碍,包括状腺功能障碍,失生症和炎症媒介.
- 表皮-介质细胞过渡 (EMT) 和紧密结的破坏是CRS病变发生的关键分子事件,特别是在带有鼻的eosinophilic CRS中.
结论:
- 表皮屏障功能障碍是CRS病变发生的关键组成部分.
- 了解屏障破坏的分子机制为新的治疗策略提供了潜力.
- 未来的研究应该专注于障碍向疗法,以改善CRS管理.
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