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Updated: Jan 28, 2026

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在2R2随机对照试验中,为结核病预防治疗使用标准剂量和高剂量里法辛的群体药动力学建模

Fajri Gafar1,2,3, Elin M Svensson4,5, Vycke Yunivita3,6

  • 1Respiratory Epidemiology and Clinical Research Unit, Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.

The Journal of infectious diseases
|January 27, 2026
PubMed
概括

用于结核病预防疗法 (TPT) 的高剂量里法辛增加了药物暴露的比例. 各国之间观察到里芬素生物可用性的显著差异,影响了TPT的有效性.

关键词:
里法皮辛 (Rifampicin) 是一种高剂量的里法皮辛.建模和模拟的模型和模拟.人口的药理动力学结核病感染 结核病感染结核病预防性治疗治疗

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