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聚合物微和纳米粒子从心肺旁路和体外膜氧化回路释放

Lars Saemann¹, Markus Stiller¹, Hardik Vaghasiya²

¹Department of Cardiac Surgery, 14942 University Hospital Halle , Halle (Saale), Germany.

Biomedizinische Technik. Biomedical engineering

|January 27, 2026

概括

心肺旁路和体外膜氧化电路释放聚合物微和纳米粒子 (MNP). 随着使用时间的推移,MNP水平会增加,这可能会导致体外循环期间的不良健康影响.

科学领域:

生物材料科学生物材料科学
医疗设备工程医疗设备工程
毒理学毒理学毒理学

背景情况:

心肺绕道 (CPB) 和体外膜氧化 (ECMO) 或生命支持 (ECLS) 电路是必不可少的医疗器械.
这些电路是由聚合物构成的,这引发了人们对微粒和纳米粒子 (MNP) 释放的担忧.
许多MNP与炎症,氧化应激和亡有关,反映了体外循环的已知副作用.

研究的目的:

调查CPB和ECMO/ECLS电路中聚合物微粒子和纳米粒子 (MNP) 的释放情况.
量化MNP释放并描述所涉及的聚合物类型.

主要方法:

CPB和ECMO/ECLS电路分别使用盐溶液运行了5小时和7天.
采集和过样本,用光学显微镜和微型拉曼光谱检测和量化MNP.

主要成果:

在CPB电路中检测到聚乙烯 (PVC) 和聚甲基甲酸 (PMMA).
在CPB中5小时后发现了聚乙烯二甲 (PET).
ECMO/ECLS电路显示了聚合物碎片的时间依赖积累,包括聚乙烯 (PE),聚烯 (PS),PET和PVC.
颗粒大小从<2μm增加到>10μm,循环时间延长.

结论:

在CPB和ECMO/ECLS电路中,可以明显地将MNP释放到循环中.
释放的MNP的数量随着电路使用的时间而增加.
需要进一步的研究来探索这些已识别的MNP对健康的影响.

关键词:

老化的老化衰老的老化通过心肺绕道术 (cardiopulmonary bypass) 进行心肺绕道术.身体外膜氧化氧化微粒子是微粒的组成部分.微塑料微塑料的使用纳米塑料的纳米塑料

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