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在患有佩茨-杰格斯综合征的儿童中,小肠聚类复发的风险因素分析:回顾性队列研究

Shiqiu Xiong^1,2, Huanyu Liu^1,2, Shan Liu^1,2

¹Department of Gastroenterology, Xi'an Children's Hospital, Xi'an, China.

Journal of pediatric gastroenterology and nutrition

|January 27, 2026

概括

在Peutz-Jeghers综合征 (PJS) 患者中,有大量大小肠小息肉增加了复发风险. 早期的多胞体查对于管理这种遗传性疾病至关重要.

科学领域:

儿科胃肠病学儿科胃肠病学
临床遗传学临床遗传学
在瘤学瘤学.

背景情况:

皮茨-杰格斯综合征 (PJS) 是一种遗传性疾病,与胃肠多,粘膜皮肤色素和癌症风险增加有关.
儿科PJS患者经常经历诸如肠接等并发症,需要重复的手术干预.

研究的目的:

确定与诊断为PJS的儿科患者中小肠小息肉复发相关的临床风险因素.

主要方法:

对64名儿科PJS患者进行了回顾性分析,至少进行了两次随访.
收集的数据包括人口统计,临床表现和内镜发现. 复发被定义为≥15毫米的息肉.
使用卡普兰-梅尔曲线和考克斯比例危险模型来确定风险因素.

主要成果:

该队列的平均年龄为8.0岁. 聚复发的中位时间为36.4个月.
在12,24和36个月的复发率分别为19.8%,33.2%,46.2%.
较高的息肉数 (≥10) 和较大的息肉直径 (≥2厘米) 与复发风险增加显著相关 (HR分别为5.61和1.20).

结论:

小肠小息肉的数量 (≥10) 和它们的直径 (≥2厘米) 是小儿PJS复发的独立预测因素.
常规和早期内镜查聚体对于管理PJS患者至关重要,即使没有症状.

关键词:

考克斯回归法考克斯回归法卡普兰·梅耶尔 (Kaplan 梅耶尔) 是一个肠道多重构成的情况.儿科患者的儿童患者.这是一项回顾性研究.

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