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单独的CTE神经病理与痴呆和认知症状有关
Rachael M Layden1, Jenna R Groh1, Annalise E Miner1
1Boston University Alzheimer's Disease Research Center and Boston University CTE Center, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
慢性创伤性脑病变 (CTE) 的高级阶段与痴呆和认知能力下降有关. 然而,在这个大脑捐赠者研究中,较轻的CTE阶段和情绪/行为症状没有明确的关联.
科学领域:
- 神经病理学神经病理学
- 神经退行性疾病 神经退行性疾病
- 大脑健康 大脑健康
背景情况:
- 慢性创伤性脑病 (CTE) 是一种神经退行性疾病,与重复的头部创伤有关.
- 了解CTE对临床症状的特定神经病理贡献至关重要.
研究的目的:
- 调查CTE神经病理和临床症状之间的独立关联.
- 确定CTE严重程度与痴呆和认知/神经精神症状的可能性之间的关系.
主要方法:
- 分析了614名大脑捐赠者,包括366名尸检确认的CTE和248名对照者.
- 排除患有其他主要神经退行性疾病的个人.
- 通过信息员报告进行认知和神经精神病学评估,痴呆症诊断由共识会议决定.
主要成果:
- 第四阶段的CTE与痴呆的几率增加了4.48倍.
- 第三阶段的CTE显示,痴呆的几率增加了2.12倍.
- 更高的CTE阶段与更多的告知者报告的认知症状相关,但不是情绪或行为症状.
结论:
- 第三阶段和第四阶段的CTE神经病理学独立地与痴呆风险增加和认知症状有关.
- 较轻度的CTE阶段 (I和II) 与认知症状或痴呆症没有显著的关联.
- 在CTE中,情绪和行为症状可能具有多因素的起源或波动的过程,并且在本研究中与CTE严重程度无关.
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