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智能再生策略具有芯片上可编程的热概况,用于可再生的诺罗病毒适应感应

Yun Bai¹, Xuan Zhou¹, Wei Zhang¹

¹College of Photoelectric Engineering, Chongqing University, Chongqing400044, China.

|January 27, 2026

概括

一种新型的体生物传感器为诺罗病毒检测提供了智能,现场再生. 这种可重复使用的传感器采用可编程的热形状,用于高效和耐用的诺罗病毒诊断.

科学领域:

生物传感器技术的技术
纳米材料是一种纳米材料.
分子诊断学分子诊断学

背景情况:

诺罗病毒 (NoV) GII.4是人类感染的主要原因,需要快速的现场检测方法.
现有的基于aptamer的生物传感器需要频繁的再生,这限制了它们在资源有限的环境中的实际应用.

研究的目的:

开发用于用于诺罗病毒检测的屏幕打印电极 (SPE) 上的aptamer生物传感器的智能再生战略.
为了提高生物传感器系统的耐用性和可重复使用性.

主要方法:

用MXene@MWCNTs-Au-Fc和ssDNA修改的丝网打印电极的制造.
组装aptamer-ssDNA结构,其中包括甲蓝 (MB) 用于信号生成.
实现微控制器单元 (MCU) 实现生物传感器可编程热再生.

主要成果:

生物传感器实现了广泛的检测范围 (1-10^6副本mL^-1) 与低的检测极限 (0.67副本mL^-1).
与对照组 (80.26%) 相比,智能再生策略显著降低了甲蓝的损失 (98.67%的保留率).
该方法在检测受污染的食品样本中的诺罗病毒方面表现出很高的准确性,与RT-qPCR结果一致 (RSDs <4.89%).

结论:

开发的具有智能再生的aptamer生物传感器为敏感和可重复使用的诺罗病毒检测提供了一个有前途的解决方案.
芯片上的热调节系统有效地平衡了反应促进和功能保护.
这项技术在资源有限的环境中对现场诊断具有重大潜力.

关键词:

在MXene@MWCNTs-Au纳米粒子中.诺罗病毒是一种病毒.可编程的热概况分量计策略的战略.更新生物传感器用丝网打印的电极.

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