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Updated: Jan 28, 2026

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结构和动力学分析β-Lactam抑制Streptococcus pneumoniae素结合蛋白1b (PBP1b) 指南 质疑结构活动关系

Parker L Flanders1, Jacob R Gillingham2, Carlos Contreras-Martel3

  • 1Department of Medicinal Chemistry, University of Minnesota, 208 Harvard Street SE, Minneapolis, Minnesota 55454, United States.

ACS chemical biology
|January 27, 2026
PubMed
概括

青素结合蛋白 (PBPs) 对细菌细胞壁至关重要. 这项研究揭示了beta-lactam抗生素结构的微妙变化如何影响它们对Streptococcus pneumoniae PBP1b的结合和效力.

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