围绕卵巢癌风险降低手术的决策:来自多元人口的观点
Luiza Perez1, Amita Kulkarni1, Laura Keenahan1
1Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY.
Menopause (New York, N.Y.)
|January 27, 2026
概括
关于BRCA1/2致病变体 (PV) 风险降低手术的决定受到手术更年期问题,生育能力和癌症史的影响. 多样化的患者观点对于文化敏感,以患者为中心的护理至关重要.
科学领域:
- 妇科瘤学 妇科瘤学
- 癌症遗传学 癌症遗传学
- 以患者为中心的护理
背景情况:
- BRCA1/2致病变体 (PV) 增加了卵巢癌的风险,需要进行降低风险的手术,如salpingo-oophorectomy.
- 目前关于患者偏好这些手术的文献主要反映了白人人口,限制了概括性.
- 了解患者决策的多样性对于公平的癌症风险管理至关重要.
研究的目的:
- 探索BRCA1/2PV携带者在种族和种族多样化的队列中进行卵巢癌风险降低手术的决策因素.
- 为了确定患者为中心的考虑,超越瘤学结果.
主要方法:
- 与15名携带BRCA1/2 PVs的患者进行了半结构面试.
- 采访被记录,转录,并通过两个独立的编码器使用诱导方法进行分析.
主要成果:
- 参与者 (平均年龄41岁) 包括各种种族/种族背景;10人被确定为西班牙裔,黑人或亚洲人.
- 关键的决定因素包括手术更年期问题,生育能力,瘤安全,乳腺癌史,性功能和心理健康.
- 十名参与者已经接受了降低风险的手术 (7 个卵管切除术,3 个卵管切除术).
结论:
- 在BRCA1/2PV载体中降低风险的妇科手术的决策是多因素的,受个人价值观和关切的影响.
- 洞察力支持临床医生为各种人群提供文化敏感和以患者为中心的护理.
- 解决患者的优先事项可以改善癌症风险管理的坚持和结果.
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