通过仿生学改进推进药物相互作用预测:利用最新的人工智能技术指导现场研究人员
Ridwan Boya Marqas1,2, Zsuzsa Simó3, Abdulazeez Mousa4
1IT Department, College of Health and Medical Technology Shekhan, Duhok Polytechnic University, Duhok 42001, Iraq.
人工智能 (AI) 方法,包括机器学习 (ML) 和深度学习 (DL),提高药物相互作用 (DDI) 预测的准确性和效率. 生物灵感和仿生方法对未来的DDI预测模型显示出希望.
科学领域:
- 药理学 药理学是指药理学的学科.
- 计算生物学 计算生物学
- 人工智能的人工智能
背景情况:
- 药物相互作用 (DDI) 存在重大风险,影响药物的疗效和患者安全.
- 对于DDI预测的传统临床试验是资源密集型和耗时的.
- 人工智能 (AI) 的进步,特别是机器学习 (ML) 和深度学习 (DL),为使用大数据集进行DDI预测提供了高效的解决方案.
研究的目的:
- 为预测药物相互作用 (DDI) 的基于AI的方法提供全面的审查.
- 在DDI预测中探索经典的ML,高级DL,基于图形的模型和整体技术.
- 调查新兴的仿生方法及其提高DDI预测模型的潜力.
主要方法:
- 复习经典的ML算法 (例如,逻辑回归,支持矢量机器).
- 分析深度学习 (DL) 模型 (例如,深度神经网络,长期短期记忆网络).
- 检查基于图形的模型 (例如,图形卷积网络,图形注意网络),知识图,变压器和仿生策略.
主要成果:
- 与传统方法相比,AI,ML和DL显著提高了DDI预测的准确性和效率.
- 生物灵感和仿生方法,如遗传算法和殖民地优化,显示出改进人工智能模型的希望.
- 该审查涵盖了数据类型和评估方法,突出了未来研究的领域.
结论:
- 人工智能驱动的DDI预测对于降低风险,改善药物结果和降低医疗保健成本至关重要.
- 仿生人工智能模型为捕捉药物相互作用的复杂性提供了一个有希望的途径.
- 需要进一步的研究来提高DDI预测模型的准确性,可用性和可解释性.
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