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灵活的喷墨打印pH传感器用于器官芯片上的生物医学测试.
Željka Boček1, Donna Danijela Dragun1, Laeticia Offner1,2
1Faculty of Chemical Engineering & Technology, University of Zagreb, Trg Marka Marulića 19, 10000 Zagreb, Croatia.
Biosensors
|January 27, 2026
概括
研究人员为芯片上的肺模型开发了喷墨打印的pH传感器. 这项技术可以实时监测模拟肺环境中的pH值变化,从而推进吸入疗法和呼吸系统研究.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 传感器技术 传感器技术
背景情况:
- 芯片上的肺模型对于研究吸入产品和药物输送至关重要.
- 肺部生理环境呈现pH值波动,需要在这些模型中进行监测.
- 现有的模型缺乏集成的,实时的pH感应能力.
研究的目的:
- 开发灵活的,小型化的,喷墨打印的pH传感器,用于集成到芯片上的肺系统中.
- 评估用于传感器制造的不同pH敏感材料和基板.
- 创建一个功能性肺上芯片模型,集成化学传感.
主要方法:
- 在柔性基板 (SPE,IJP-Gr) 上喷墨打印pH敏感材料 (可塑化PVC,聚氨酸).
- 电位计传感器的制造和表征,包括灵敏度和稳定性测试.
- 优化传感器与具有电膜和酸盐的肺在芯片模型的集成.
主要成果:
- 一个生物相容,喷墨打印的聚氨酸传感器与一个Ag/AgCl准参考电极配对,证明了Nernstian灵敏度 (58.8 mV/pH).
- 传感器系统表现出良好的可重现性,可逆性和潜在的稳定性.
- 集成的肺上芯片模型成功监测了在乙酸气溶暴露期间的pH值变化,评估了透性.
结论:
- 喷墨打印的微传感器与电-水凝材料相结合,增强了用于研究气溶动力学和化学环境的芯片上的肺模型.
- 该平台将机械性能与化学传感相结合,为呼吸系统研究和吸入治疗开发提供了一种新的方法.
- 开发的系统为模拟和分析复杂的肺部疾病提供了宝贵的工具.
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