血红素作为诊断生物标志物:对下一代疟疾检测技术的全面审查
Afiat Berbudi1,2, Shafia Khairani3,4, Alexander Kwarteng5
1Department of Biomedical Sciences, Parasitology Division, Faculty of Medicine, Universitas Padjadjaran, Bandung 40161, Indonesia.
Biosensors
|January 27, 2026
概括
血红素检测提供了一种新的疟疾诊断方法. 磁光学器件在现场使用方面表现有前途,但需要进一步的研究来灵敏地检测低水平的寄生虫.
科学领域:
- 疟疾诊断的诊断方法
- 生物标志物检测检测 生物标志物检测
- 寄生虫学的寄生虫学
背景情况:
- 目前的疟疾诊断方法在灵敏度,操作要求和现场适用性方面存在局限性.
- 血红素是一种由菌产生的生物标志物,为先进的诊断提供了一个无试剂的目标.
- 准确的诊断对于疟疾病例管理和控制传播至关重要.
研究的目的:
- 审查和综合基于hemozoin的疟疾检测技术的最新进展.
- 绘制当前的血红素检测平台的地图.
- 为未来的疟疾诊断确定有前途的技术.
主要方法:
- 根据PRISMA-ScR和Joanna Briggs研究所的指导方针进行范围审查.
- 对24项关于血红素检测技术的研究进行了系统审查.
- 将技术分为八大类的分类.
主要成果:
- 磁光系统 (例如,Hz-MOD,GazelleTM,RMOD) 显示出高度的操作准备性,但在低寄生病率下敏感性有限.
- 光声学检测 (Cytophone) 显示出有希望的灵敏度和体内检测能力.
- 拉曼/SERS光谱具有高分析灵敏度,但仅限于实验室;微流体和智能手机工具正在成为低成本替代品.
结论:
- 血红素向诊断是一种快速发展的领域,具有多个转化途径.
- 磁光设备最接近现场部署,需要进一步的临床验证.
- 改进的低密度检测和标准化的比较对于在疟疾流行地区的广泛采用至关重要.
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