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较低的HALP得分预测了发烧性中性衰竭的固体瘤患者长期住院的情况
Salih Karatlı1, Doğan Yazılıtaş1
1Department of Medical Oncology, Etlik City Hospital, 06170 Ankara, Türkiye.
Current oncology (Toronto, Ont.)
|January 27, 2026
概括
低血红蛋白-白-淋巴细胞-血小板 (HALP) 评分和较高的稳定发烧性中性质的临床指数 (CISNE) 评分预测发烧性中性质 (FN) 患者的住院时间更长. 微生物培养的阳性也表明长时间住院治疗.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 临床生物化学 临床生物化学
背景情况:
- 发烧性中性衰竭 (FN) 是固体瘤患者的关键化疗并发症.
- 早期识别患有长期住院风险的患者对于资源分配和患者管理至关重要.
研究的目的:
- 评估免疫营养指数和临床评分的预测价值,用于长时间住院治疗的成年人与FN.
- 为了确定简单的,可访问的生物标志物用于早期风险分层在FN患者.
主要方法:
- 对169名因FN而入院的成年患者进行了回顾性分析.
- 血红蛋白-白蛋白-淋巴细胞-血小板 (HALP) 评分,预后营养指数 (PNI),C反应蛋白/白蛋白比率 (CAR) 和稳定发烧性中性衰竭 (CISNE) 临床指数的计算.
- 后勤回归分析以确定长时间住院 (定义为>9天) 的预测因素.
主要成果:
- 在单变量分析中,低HALP得分,低PNI,中/高CISNE得分和阳性微生物培养与长时间住院有关.
- 在多变量模型中,低HALP得分,中等/高CISNE得分和积极的微生物培养仍然是独立的预测因素.
- HALP与住院时间有显著的负相关性 (r = -0.469; p < 0.001).
结论:
- 低HALP得分,较高的CISNE风险类别和微生物培养的阳性是NF中长时间住院的独立预测因素.
- 简单且廉价的标记HALP得分,可以帮助早期评估NF风险.
- 将HALP与CISNE等临床工具相结合,可以改善FN患者的风险分层.
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