肝细胞癌24小时全天候
1Clínica Universitária de Gastrenterologia, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisbon, Portugal.
Current oncology (Toronto, Ont.)
|January 27, 2026
概括
现代生活方式扰乱了人类的昼夜循环,增加了癌症风险. 本综述探讨了昼夜干扰如何影响肝癌 (肝细胞癌) 的发展,预后和治疗有效性.
科学领域:
- 时间生物学 时间生物学
- 在瘤学瘤学.
- 肝病学 肝病学是一种肝病学.
背景情况:
- 现代生活方式,包括轮班工作和人工光照,破坏了人类的昼夜循环.
- 循环节障碍是2A组致癌物,与肝细胞癌 (HCC) 率的上升有关,特别是在西方国家.
- 肥胖和脂肪性肝病是HCC的主要驱动因素,新出现的证据暗示其病变发生过程中存在昼夜干扰.
研究的目的:
- 审查目前关于昼夜干扰在肝细胞癌 (HCC) 发病过程中的作用的文献.
- 检查昼夜干扰对HCC预后和治疗的影响.
- 讨论慢性治疗在改善HCC治疗结果方面的潜力.
主要方法:
- 对实验临床前数据和流行病学研究的文献综述.
- 对与HCC的昼夜调节相关的分子特征的分析.
- 对慢性疗法和免疫疗法的有效性研究的评估.
主要成果:
- 在昼夜干扰和HCC发展之间发现了强烈的关联.
- 循环节调节分子签名准确地预测HCC患者的预后.
- 免疫检查点抑制剂的早晨给药可能会提高免疫治疗的有效性.
结论:
- 循环节障碍是HCC病原和预后的一个重要因素.
- 慢性疗法,特别是免疫疗法的时间表,显示出改善HCC治疗的希望.
- 进一步研究昼夜节律在肝癌中的作用是有必要的.
相关概念视频
02:45Biological Clocks and Seasonal Responses
41.7K
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
41.7K
02:13Types of Hormones
83.3K
Hormones can be classified into three main types based on their chemical structures: steroids, peptides, and amines. Their actions are mediated by the specific receptors they bind to on target cells.
83.3K
02:35Chromatin Position Affects Gene Expression
24.8K
Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area.
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
24.8K