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Updated: Jan 28, 2026

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菌GPCR基因家族的识别和分类

Zhiyin Liu^1,2, Asaf Salamov¹, Igor V Grigoriev^1,2

¹U.S. Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

Journal of fungi (Basel, Switzerland)

|January 27, 2026

概括

这项研究统一了真菌G蛋白结合受体 (GPCRs),分类了1357个物种中的28,294个受体. 它揭示了新的GPCR及其进化模式,增强了我们对真菌信号通路的理解.

科学领域:

菌类学菌类学是指菌类学.
生物化学生物化学
基因组学就是基因组学.

背景情况:

G蛋白结合受体 (GPCR) 是真核生物信号转导的重要跨膜蛋白.
之前的研究已经确定了14种真菌GPCR类型和3种哺乳动物同类物,但它们的分布尚未检查.
缺乏一种统一的真菌GPCRs分类.

研究的目的:

建立一个全面的,统一的真菌GPCRs分类.
分析GPCRs在真菌物种中的分布和进化模式.
识别新型真菌GPCR候选物并预测它们的功能.

主要方法:

将14个真菌和3个哺乳动物的GPCR组集成到一个统一的分类系统中.
从1357种真菌中分类了28,294个GPCR.
采用定制卷积神经网络 (CNN) 进行新型GPCR识别和AlphaFold Multimer进行交互预测.

主要成果:

在真菌中建立了17个GPCR类的统一分类,显著扩大了已知的曲目.
揭示了不同的分布模式:哺乳动物同类在早期分离真菌 (EDF) 中普遍存在,而其他类主导阿斯科米科塔和巴西迪奥米科塔.
确定了Pth11类GPCRs作为Pezizomycotina中最丰富的类,与真菌致病性有关,有证据表明血统特异性减少.
使用CNN发现了假定的新型真菌GPCRs,通过G-alpha蛋白相互作用预测功能相关性.

结论:

定义了第一个大规模的,菌GPCRs的统一分类.
在真菌GPCR谱中发现了谱系特定的扩张和收缩.
确定了新型GPCR候选物,在真菌信号传递中具有潜在作用,为研究开辟了新的途径.

关键词:

与G蛋白结合的受体是G蛋白结合的受体.菌基因组学菌基因组学蛋白质结构蛋白质结构信号传输,信号传输.

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