侵入性角膜炎的诊断生物标志物:以临床医生为导向的审查
Sebastian George Smadu1,2, Simona Camelia Tetradov1,2, Luminita Ene2
1Department of Infectious Diseases, "Carol Davila" University of Medicine and Pharmacy, 37 Dionisie Lupu Street, 020021 Bucharest, Romania.
Journal of fungi (Basel, Switzerland)
|January 27, 2026
概括
通过将新型生物标志物与传统方法相结合,可以改进对侵袭性角膜炎的诊断. 这种方法旨在加快诊断和促进早期治疗,以获得更好的患者结果.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 临床诊断 临床诊断 临床诊断
背景情况:
- 侵袭性候群病是一种严重的感染,由Candida物种引起,特别影响住院和免疫受损患者.
- 目前的诊断方法,如血培养,在敏感度上有局限性,这给及时和准确的诊断带来了挑战.
- 早期和有效的治疗对于管理侵袭性角膜病的重大负担至关重要.
研究的目的:
- 审查和评估临床适用的生物标志物来诊断侵袭性 кандидоз.
- 评估各种诊断生物标志物的性能.
- 开发一种用于实际临床使用的诊断算法.
主要方法:
- 使用PubMed和Scopus进行了1990年至2025年间发表的研究的叙事审查.
- 关键词包括侵入性角膜炎和非培养诊断生物标志物.
- 此外,还审查了临床指南和共识文件.
主要成果:
- 血液培养,黄金标准,具有较低的灵敏度 (50%).
- 聚合酶链反应 (PCR) 试验具有高特异性 (91-98%),但由于成本和物种识别而受到限制.
- 非培养的血清测试 (曼南,抗曼南,1-3-β-D-葡萄糖) 显示出有希望的敏感性和特异性,用于高风险患者的早期检测.
结论:
- 将新型生物标志物集成到诊断途径中可以增强侵袭性角膜炎的传统黄金标准.
- 结合生物标志物有可能缩短诊断时间.
- 这种综合方法可以促进早期获得治疗,改善患者的治疗结果.
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