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Updated: Jan 28, 2026

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AP-1西格玛子单元基因PsAP1通过调节Puccinia striiformis f. sp. 中的代谢重编程,作为关键的致病因子. 在"tritici"一书中,

Beibei Liu¹, Jianing Wu², Guoshuai Zhang¹

¹Key Laboratory of Biological Ecological Adaptation and Evolution in Extreme Environments, College of Life Science, Xinjiang Agricultural University, Urumqi 830052, China.

Journal of fungi (Basel, Switzerland)

|January 27, 2026

概括

研究人员确定了PsAP1,这是一种对小麦条纹 (Puccinia striiformis) 感染至关重要的蛋白质. 沉默这种基因显著降低了真菌生长和病原性,突出了PsAP1作为疾病控制的潜在目标.

科学领域:

植物病理学植物病理学
分子生物学分子生物学
菌类遗传学菌类遗传学

背景情况:

小麦条纹生,是由*Puccinia striiformis* f. sp. 引起的 *tritici* (Pst),对全球小麦产量构成重大威胁.
适应蛋白复合体AP-1在菌中的作用在很大程度上是未知的,尽管它在囊泡贩运中的重要性.

研究的目的:

为了研究AP-1 σ子单元 (PsAP1) 在Pst病原性中的功能.
探索PsAP1作为控制小麦条纹生的潜在目标.

主要方法:

在Pst.中识别和表征PsAP1基因.
在*Fusarium graminearum*中使用异质表达来评估功能补充.
亚细胞局部化研究.
在小麦中使用大麦条纹马赛克病毒 (BSMV) 的宿主诱导基因沉默 (HIGS).
转录组分析以了解途径中断.

主要成果:

在Pst感染早期阶段诱导了PsAP1的表达.
沉默PsAP1显著降低了Pst菌根的生长,化和病原体生物量.
沉默PsAP1增强了宿主反应性氧物种的积累,并破坏了MAPK信号,谷和碳水化合物代谢途径.
PsAP1局部存在于血,细胞质和细胞核中.

结论:

PsAP1对于Pst的致病性至关重要,通过调节囊泡流通,抑制宿主免疫力和重新编程宿主新陈代谢来促进感染.
准PsAP1为开发新的小麦条纹生控制措施提供了一个有希望的策略.

关键词:

AP-1复合体 AP-1复合体是一个复合体.这是一个很高的高度.代谢重编程是指代谢重编程.小麦条纹生的生.

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