甲基治疗失败的遗传标记 在牛皮的治疗失败
Maria N Vikhreva1, Lavrenty G Danilov2, Andrey A Martynov3
1Penza Institute for Advanced Medical Education-Branch of the Federal State Budgetary Educational Institution of Further Professional Education "Russian Medical Academy of Continuous Professional Education" of the Ministry of Healthcare of the Russian Federation, 8A Stasov Str., Penza 440060, Russia.
Journal of personalized medicine
|January 27, 2026
概括
SLC19A1和COL18A1的遗传变异与牛皮患者的甲状腺素不耐受有关. 这些发现可能有助于预测哪些患者需要从甲状腺素转换为生物疗法.
科学领域:
- 药物遗传学 药物遗传学
- 皮肤病学 皮肤病学
- 遗传学 是一个遗传学.
背景情况:
- 治疗中度至重度牛皮的甲托雷克萨特 (MTX) 治疗可能会导致不耐受性或有效性降低,需要转向生物药物.
- 在这种情况下,影响MTX药理动学的药物遗传标志物尚未得到充分研究.
- 转运体和酶的遗传变异可以预测MTX反应和副作用.
研究的目的:
- 在牛皮患者中调查与MTX不耐受或效率不足相关的遗传变异.
- 为了确定从MTX切换到生物治疗的药物遗传学预测因素.
主要方法:
- 在80名中度至重度牛皮患者中分析了载体和代谢基因中的12种多态.
- 将转换为生物药物的患者 (n=43) 和继续使用MTX的患者 (n=37) 之间的基因型频率进行比较.
- 利用下一代测序来进行多态性分析.
主要成果:
- 在SLC19A1 rs1051266 (p=0.03) 和COL18A1 rs9977268 (p=0.02) 的基因型频率中发现了显著的差异.
- 在需要生物治疗的患者中,SLC19A1和COL18A1的T等位基载体更常见.
- 这表明与MTX不耐受或降低疗效的潜在关联.
结论:
- 在SLC19A1 rs1051266和COL18A1 rs9977268中的多态性与在牛皮中需要从MTX转换为生物药物有关.
- 这些基因中的C等位基因携带者可能面临甲状腺素不耐症的风险增加.
- 这些遗传标记物可以帮助 psoriasis 患者个性化治疗决策.
相关概念视频
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure
611
Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
611
Genetics of Speciation
21.0K
Speciation is the evolutionary process resulting in the formation of new, distinct species—groups of reproductively isolated populations.
21.0K
What is Population Genetics?
64.6K
A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
64.6K
What is Genetic Engineering?
80.0K
Overview
80.0K
Pathophysiology of Heart Failure
3.4K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
3.4K
Heart Failure I: Introduction
829
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
829


