基线和动态中性粒细胞与淋巴细胞比率作为转移性结直肠癌患者的预后生物标志物,这些患者接受了Panitumumab治疗
Teodor Marian Vancea1, Andrada Olivia Tapirdea1, Mihai Gabriel Zait1
1Faculty of Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania.
Journal of personalized medicine
|January 27, 2026
概括
中性粒细胞与淋巴细胞的比率 (NLR) 可以预测在接受抗EGFR治疗的转移性结直肠癌 (mCRC) 患者的治疗成功. 较低的基线NLR和在治疗期间增加的NLR与更长的无进展生存期 (PFS) 有关.
科学领域:
- 在瘤学瘤学.
- 生物标志物 生物标志物
- 癌症研究 癌症研究
背景情况:
- 结肠直肠癌 (CRC) 是全球癌症死亡的主要原因之一.
- 皮表皮生长因子受体 (EGFR) 抑制剂增强了转移性CRC (mCRC) 患者的KRAS野生型瘤的结果.
- 通过中性粒细胞与淋巴细胞比率 (NLR) 评估的炎症可能会影响治疗疗效.
研究的目的:
- 为了研究基线NLR (bNLR) 和动态NLR变化 (ΔNLR) 的预后值,mCRC患者接受一线化疗加上panitumumab治疗.
- 确定NLR是否可以预测该患者队列的无进展生存期 (PFS).
主要方法:
- 对44名患有左侧,KRAS野生型mCRC的患者进行了回顾性分析,这些患者接受了FOLFOX/FOLFIRI加上panitumumab.
- 在基线 (bNLR) 和四个治疗周期 (ΔNLR) 后评估NLR.
- 无进展生存 (PFS) 是主要终点,使用ROC曲线和多变量分析进行分析.
主要成果:
- 确定了3.06的最佳bNLR截止值 (AUC = 0.78,p = 0.004) 的结果.
- 低bNLR (≤3.06) 的患者与高bNLR (>3.06) (7个月,HR = 2.7,p = 0.002) 的患者相比,PFS显著更长 (14个月).
- 阳性 ΔNLR 的患者表现出优异的 PFS (18 个月) 与阴性 ΔNLR 的患者 (11 个月,HR = 0.47,p = 0.022).
- 多变量分析证实bNLR是PFS的独立预测因子.
结论:
- 基线NLR (bNLR) 和动态NLR变化 (ΔNLR) 在接受抗EGFR治疗的mCRC患者中显示出预后价值.
- 对于预测治疗结果,NLR 作为一个具有成本效益的生物标志物.
- 这些发现支持将NLR评估纳入临床实践,以实现个性化的mCRC治疗策略.
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